The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells. - Wikidata - awgldk - TriplyDB

The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells.

The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells.

http://www.wikidata.org/entity/Q33711057

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Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions The IL-17 pathway as a major therapeutic target in autoimmune diseases Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling CD40 regulates the processing of NF-kappaB2 p100 to p52 Affinity of antigen encounter and other early B-cell signals determine B-cell fate.TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses.TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile The rise and fall of long-lived humoral immunity: terminal differentiation of plasma cells in health and disease.Reduction of CD1d expression in vivo minimally affects NKT-enhanced antibody production but boosts B-cell memory.Proinflammatory responses induced by CD40 in retinal endothelial and Müller cells are inhibited by blocking CD40-Traf2,3 or CD40-Traf6 signaling.Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies.TNF-receptor-associated factors as targets for drug development.Act1, a U-box E3 ubiquitin ligase for IL-17 signaling.Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes.Increased p190RhoGEF expression in activated B cells correlates with the induction of the plasma cell differentiation.The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation CD40-TRAF Signaling Upregulates CX3CL1 and TNF-α in Human Aortic Endothelial Cells but Not in Retinal Endothelial Cells.Type II membrane protein CD69 regulates the formation of resting T-helper memory.Transmembrane activator and calcium modulator and cyclophilin ligand interactor enhances CD40-driven plasma cell differentiation Upregulation of tumor necrosis factor receptor-associated factor 6 correlated with synovitis severity in rheumatoid arthritis RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation.TACI and BAFF-R mediate isotype switching in B cells Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes The programmed death-1 and interleukin-10 pathways play a down-modulatory role in LP-BM5 retrovirus-induced murine immunodeficiency syndrome.TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40.Molecular mechanism and function of CD40/CD40L engagement in the immune system.Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance.TRAF6 is a critical regulator of LMP1 functions in vivo.The fourth dimension in immunological space: how the struggle for nutrients selects high-affinity lymphocytes.Regulation of atherosclerotic plaque inflammation.Tumor necrosis factor receptor- associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system.Blockade of CD40-TRAF2,3 or CD40-TRAF6 is sufficient to inhibit pro-inflammatory responses in non-haematopoietic cells.Modeling the chronic lymphocytic leukemia microenvironment in vitro.TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells Transmembrane domains 1 and 2 of the latent membrane protein 1 of Epstein-Barr virus contain a lipid raft targeting signal and play a critical role in cytostasis.Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.TRAF6 specifically contributes to FcepsilonRI-mediated cytokine production but not mast cell degranulation.Tumor necrosis factor-alpha and CD40L modulate cell surface morphology and induce aggregation in Ramos Burkitt's lymphoma cells.

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The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells.

http://www.wikidata.org/entity/Q33711057

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2002 թվականի ապրիլին հրատարակված գիտական հոդված

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2002年の論文

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Nature Immunology

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The CD40-TRAF6 axis controls a ...... on of long-lived plasma cells.

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P2093

Brian O'Connor

http://www.w3.org/2001/XMLSchema#string

Cory Ahonen

http://www.w3.org/2001/XMLSchema#string

Eric Manning

http://www.w3.org/2001/XMLSchema#string

Evan F Lind

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Loren D Erickson

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Marilyn R Kehry

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Randolph J Noelle

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Steven S Pullen

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P2860

A novel RING finger protein interacts with the cytoplasmic domain of CD40

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor

Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40

The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators

The CD40 antigen and its ligand

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation

Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice

CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.

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451-456

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10.1038/NI792

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5

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3

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2002-04-22T00:00:00Z

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11399816

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11967542

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2834483

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