Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors.
about
Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathwayLoss of constitutive activity of the growth hormone secretagogue receptor in familial short statureThe chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalizationThe further redefining of steroid-mediated signalingIn vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?The second transmembrane domain of the human type 1 angiotensin II receptor participates in the formation of the ligand binding pocket and undergoes integral pivoting movement during the process of receptor activationThe structural basis of arrestin-mediated regulation of G-protein-coupled receptorsRecovery of neuronal and network excitability after spinal cord injury and implications for spasticityCellular mechanisms of the 5-HT7 receptor-mediated signalingExpression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoaAn optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptorsOvarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancerHuman and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonistsEngineering GPCR signaling pathways with RASSLsModifying ligand-induced and constitutive signaling of the human 5-HT4 receptorChemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signallingA "genome-to-lead" approach for insecticide discovery: pharmacological characterization and screening of Aedes aegypti D(1)-like dopamine receptorsHow genetic errors in GPCRs affect their function: Possible therapeutic strategiesGpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviourThe role of experimental and computational structural approaches in 7TM drug discovery.Exploring the mechanism of F282L mutation-caused constitutive activity of GPCR by a computational study.Naturally occurring HCA1 missense mutations result in loss of function: potential impact on lipid deposition.Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.Functional reconstitution of the human chemokine receptor CXCR4 with G(i)/G (o)-proteins in Sf9 insect cellsRecovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors.Structure-function of the G protein-coupled receptor superfamily.Signaling of human frizzled receptors to the mating pathway in yeast.Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2.Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo.Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor.Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress.Pharmacological characterization of human incretin receptor missense variantsAnalysis of transmembrane domains 1 and 4 of the human angiotensin II AT1 receptor by cysteine-scanning mutagenesis.Molecular cloning and characterization of crustacean type-one dopamine receptors: D1alphaPan and D1betaPan.GPCR and G proteins: drug efficacy and activation in live cells.Salt bridge integrates GPCR activation with protein traffickingModulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons.Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations.Allosteric sodium in class A GPCR signalingPreservation of eumelanin hair pigmentation in proopiomelanocortin-deficient mice on a nonagouti (a/a) genetic background.
P2860
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P2860
Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors.
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Constitutive activity of G-pro ...... operty of wild-type receptors.
@ast
Constitutive activity of G-pro ...... operty of wild-type receptors.
@en
Constitutive activity of G-pro ...... operty of wild-type receptors.
@nl
type
label
Constitutive activity of G-pro ...... operty of wild-type receptors.
@ast
Constitutive activity of G-pro ...... operty of wild-type receptors.
@en
Constitutive activity of G-pro ...... operty of wild-type receptors.
@nl
prefLabel
Constitutive activity of G-pro ...... operty of wild-type receptors.
@ast
Constitutive activity of G-pro ...... operty of wild-type receptors.
@en
Constitutive activity of G-pro ...... operty of wild-type receptors.
@nl
P1476
Constitutive activity of G-pro ...... operty of wild-type receptors.
@en
P2093
Katharina Wenzel-Seifert
Roland Seifert
P2888
P304
P356
10.1007/S00210-002-0588-0
P577
2002-09-06T00:00:00Z
P6179
1038974542