Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization - Wikidata - awgldk - TriplyDB

Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization

Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization

http://www.wikidata.org/entity/Q33759201

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Chromatin regulation and genome maintenance by mammalian SIRT6 Role of Sirtuins in Linking Metabolic Syndrome with Depression A dynamic interface between ubiquitylation and cAMP signaling Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NFκB responses Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes.Identification of novel interacting partners of Sirtuin6.Pathways for ischemic cytoprotection: role of sirtuins in caloric restriction, resveratrol, and ischemic preconditioning.Structure and biochemical functions of SIRT6.SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling Posttranslational modification of Sirt6 activity by peroxynitrite.Synthesis and characterization of SIRT6 protein coated magnetic beads: identification of a novel inhibitor of SIRT6 deacetylase from medicinal plant extracts.The human sirtuin family: evolutionary divergences and functions.SIRT6/NF-κB signaling axis in ginsenoside Rg1-delayed hematopoietic stem/progenitor cell senescence Using mitochondrial sirtuins as drug targets: disease implications and available compounds.Sirtuin-dependent clock control: new advances in metabolism, aging and cancer Sub-cellular localization, expression and functions of Sirt6 during the cell cycle in HeLa cells Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development.The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses Proteomic analysis of the SIRT6 interactome: novel links to genome maintenance and cellular stress signaling.A proteomic perspective of Sirtuin 6 (SIRT6) phosphorylation and interactions and their dependence on its catalytic activity.Chromatin and beyond: the multitasking roles for SIRT6 Molecular pathways: emerging roles of mammalian Sirtuin SIRT7 in cancer Regulation of sirtuin function by posttranslational modifications Sirtuin 6: a review of biological effects and potential therapeutic properties.Sirtuins and the circadian clock: bridging chromatin and metabolism.Role of sirtuins in chronic obstructive pulmonary disease.Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair.The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.Identifying the functional contribution of the defatty-acylase activity of SIRT6.Changes in human sirtuin 6 gene promoter methylation during aging.Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol.Structures, substrates, and regulators of Mammalian sirtuins - opportunities and challenges for drug development.SIRT6 exhibits nucleosome-dependent deacetylase activity Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features.Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6.A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity.A Review of the Recent Advances Made with SIRT6 and its Implications on Aging Related Processes, Major Human Diseases, and Possible Therapeutic Targets

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P2860

Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization

http://www.wikidata.org/entity/Q33759201

description

2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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name

Functional dissection of SIRT6 ...... ity and chromatin localization

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Functional dissection of SIRT6 ...... ity and chromatin localization

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type

label

Functional dissection of SIRT6 ...... ity and chromatin localization

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Functional dissection of SIRT6 ...... ity and chromatin localization

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prefLabel

Functional dissection of SIRT6 ...... ity and chromatin localization

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Functional dissection of SIRT6 ...... ity and chromatin localization

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J.MAD.2010.01.006

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Mechanisms of Ageing and Development

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Functional dissection of SIRT6 ...... ity and chromatin localization

@en

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Elisabeth Berber

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Katrin F Chua

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Ruth I Tennen

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P2860

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

The macro domain is an ADP-ribose binding module

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185-192

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scholarly article

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10.1016/J.MAD.2010.01.006

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20117128

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