Transcriptional silencing is defined by isoform- and heterodimer-specific interactions between nuclear hormone receptors and corepressors
about
Transcriptional repression by the insulator protein CTCF involves histone deacetylasesArsenic trioxide is a potent inhibitor of the interaction of SMRT corepressor with Its transcription factor partners, including the PML-retinoic acid receptor alpha oncoprotein found in human acute promyelocytic leukemiaLigand-specific dynamics of the androgen receptor at its response element in living cellsRole of Nuclear Receptors in Central Nervous System Development and Associated DiseasesA unique secondary-structure switch controls constitutive gene repression by retinoic acid receptorThe SMRT corepressor is a target of phosphorylation by protein kinase CK2 (casein kinase II)Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cyclingRetinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouseThyroid hormone receptors mutated in liver cancer function as distorted antimorphsRescue of a primary myelofibrosis model by retinoid-antagonist therapyThe CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors.Disrupting the enzyme complex regulating O-GlcNAcylation blocks signaling and development.Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants.Isotype-restricted corepressor recruitment: a constitutively closed helix 12 conformation in retinoic acid receptors beta and gamma interferes with corepressor recruitment and prevents transcriptional repression.Molecular determinants of nuclear receptor-corepressor interaction.Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation.SMRTε, a corepressor variant, interacts with a restricted subset of nuclear receptors, including the retinoic acid receptors α and βResearch resource: identification of novel coregulators specific for thyroid hormone receptor-β2.Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing.Transcriptional anti-repression. Thyroid hormone receptor beta-2 recruits SMRT corepressor but interferes with subsequent assembly of a functional corepressor complex.Retinoid isomers differ in the ability to induce release of SMRT corepressor from retinoic acid receptor-alphaThyroid hormone receptor mutations found in renal clear cell carcinomas alter corepressor release and reveal helix 12 as key determinant of corepressor specificity.Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptorsLiganded RARalpha and RARgamma interact with but are repressed by TNIP1.Vitamin D-dependent recruitment of corepressors to vitamin D/retinoid X receptor heterodimersA novel role for helix 12 of retinoid X receptor in regulating repression.The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export.Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements.Transcriptional repression by thyroid hormone receptors. A role for receptor homodimers in the recruitment of SMRT corepressor.The activity of the activation function 2 of the human hepatocyte nuclear factor 4 (HNF-4alpha) is differently modulated by F domains from various origins.Interactions of ultraspiracle with ecdysone receptor in the transduction of ecdysone- and juvenile hormone-signaling.Protein kinase C theta modulates nuclear receptor-corepressor interaction during T cell activation.Requirement for RAR-mediated gene repression in skeletal progenitor differentiation.Co-regulator recruitment and the mechanism of retinoic acid receptor synergy.
P2860
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P2860
Transcriptional silencing is defined by isoform- and heterodimer-specific interactions between nuclear hormone receptors and corepressors
description
1998 nî lūn-bûn
@nan
1998 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Transcriptional silencing is d ...... one receptors and corepressors
@ast
Transcriptional silencing is d ...... one receptors and corepressors
@en
type
label
Transcriptional silencing is d ...... one receptors and corepressors
@ast
Transcriptional silencing is d ...... one receptors and corepressors
@en
prefLabel
Transcriptional silencing is d ...... one receptors and corepressors
@ast
Transcriptional silencing is d ...... one receptors and corepressors
@en
P2860
P356
P1476
Transcriptional silencing is d ...... one receptors and corepressors
@en
P2093
M L Privalsky
P2860
P304
P356
10.1128/MCB.18.10.5724
P407
P577
1998-10-01T00:00:00Z