Targeting the OB-Folds of Replication Protein A with Small Molecules
about
Surface Reengineering of RPA70N Enables Cocrystallization with an Inhibitor of the Replication Protein A Interaction Motif of ATR Interacting ProteinDiscovery of a Potent Inhibitor of Replication Protein A Protein–Protein Interactions Using a Fragment-Linking ApproachSmall molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods.Novel irreversible small molecule inhibitors of replication protein A display single-agent activity and synergize with cisplatinRPA inhibition increases replication stress and suppresses tumor growth.Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancerDNA repair: from genome maintenance to biomarker and therapeutic target.Identification and Optimization of Anthranilic Acid Based Inhibitors of Replication Protein AIdentification of inhibitors for single-stranded DNA-binding proteins in eubacteria.
P2860
Q27679772-22251C8B-65AB-4D15-A7FB-C70AD91B6CCEQ27680422-9BEA3AEF-2F53-41C0-97F1-F076FBD5DCF1Q33860865-FB759644-C5BF-49D1-995A-9470D9974F52Q33994331-D93922D7-77F5-4454-B777-7492B0A021A4Q34362555-A6161398-9130-4BA6-8BAF-6BD2C5380E51Q34849073-8E9005D1-D381-44D5-B3DB-4CBEF85A3816Q35555880-3616AC22-42A9-4160-9E20-6617B3376A31Q35889507-60395432-B659-40F5-863C-2B114EAF9717Q40546658-B2CF642F-1D56-4C5F-ADB9-07E066D1E4F1
P2860
Targeting the OB-Folds of Replication Protein A with Small Molecules
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Targeting the OB-Folds of Replication Protein A with Small Molecules
@ast
Targeting the OB-Folds of Replication Protein A with Small Molecules
@en
type
label
Targeting the OB-Folds of Replication Protein A with Small Molecules
@ast
Targeting the OB-Folds of Replication Protein A with Small Molecules
@en
prefLabel
Targeting the OB-Folds of Replication Protein A with Small Molecules
@ast
Targeting the OB-Folds of Replication Protein A with Small Molecules
@en
P2093
P2860
P356
P1476
Targeting the OB-Folds of Replication Protein A with Small Molecules
@en
P2093
Jennifer N Earley
John J Turchi
Richard W Fitch
Sarah C Shuck
Victor J Anciano Granadillo
P2860
P304
P356
10.4061/2010/304035
P577
2010-12-06T00:00:00Z