about
Crystal structure of the human Hsmar1-derived transposase domain in the DNA repair enzyme MetnaseThe DDN catalytic motif is required for Metnase functions in non-homologous end joining (NHEJ) repair and replication restartBiochemical characterization of a SET and transposase fusion protein, Metnase: its DNA binding and DNA cleavage activityA host-guest approach for determining drug-DNA interactions: an example using netropsinThe crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor.Crystal structure of the DNA-binding domain from Ndt80, a transcriptional activator required for meiosis in yeast.Staying straight with A-tracts: a DNA analog of the HIV-1 polypurine tractCrystal structure of DNA-bound Co(III){middle dot}bleomycin B2: Insights on intercalation and minor groove bindingCrystal Structure of a Trypanocidal 4,4′-Bis(imidazolinylamino)diphenylamine Bound to DNA ,The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognitionCrystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and MammalsSum1 and Ndt80 proteins compete for binding to middle sporulation element sequences that control meiotic gene expression.Consecutive non-natural PZ nucleobase pairs in DNA impact helical structure as seen in 50 μs molecular dynamics simulations.Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells.Targeting the OB-Folds of Replication Protein A with Small MoleculesRedox regulation of DNA repair: implications for human health and cancer therapeutic development.High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.The crystal structure of 5-keto-4-deoxyuronate isomerase from Escherichia coli.Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1.Interactions of apurinic/apyrimidinic endonuclease with a redox inhibitor: evidence for an alternate conformation of the enzyme.Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondiiCrystal structures of oligonucleotides including the integrase processing site of the Moloney murine leukemia virus.Characterization of the redox activity and disulfide bond formation in apurinic/apyrimidinic endonuclease.APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neuronsS-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity.Structural basis for a six nucleotide genetic alphabet.A high-throughput, high-resolution strategy for the study of site-selective DNA binding agents: analysis of a "highly twisted" benzimidazole-diamidine.Unusually strong binding to the DNA minor groove by a highly twisted benzimidazole diphenylether: induced fit and bound waterRole of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited.Crystallization of and selenomethionine phasing strategy for a SETMAR-DNA complexStructural and energetic characterization of nucleic acid-binding to the fingers domain of Moloney murine leukemia virus reverse transcriptase.Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound libraryPhosphorylation of SIMPL modulates RelA-associated NF-kappaB-dependent transcription.Characterization of critical interactions between Ndt80 and MSE DNA defining a novel family of Ig-fold transcription factors.Differential multimerization of Moloney murine leukemia virus integrase purified under nondenaturing conditions.The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus.Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotideCrystallographic studies of a novel DNA-binding domain from the yeast transcriptional activator Ndt80
P50
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P50
description
Academic
@en
name
Millie M. Georgiadis
@ast
Millie M. Georgiadis
@en
Millie M. Georgiadis
@es
Millie M. Georgiadis
@nl
type
label
Millie M. Georgiadis
@ast
Millie M. Georgiadis
@en
Millie M. Georgiadis
@es
Millie M. Georgiadis
@nl
prefLabel
Millie M. Georgiadis
@ast
Millie M. Georgiadis
@en
Millie M. Georgiadis
@es
Millie M. Georgiadis
@nl