Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.
about
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesOverview of Alzheimer's Disease and Some Therapeutic Approaches Targeting Aβ by Using Several Synthetic and Herbal CompoundsA Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms.8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applicationsStructure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer's disease.Metalation kinetics of the human α-metallothionein 1a fragment is dependent on the fluxional structure of the apo-protein.Synthesis and characterization of some water soluble Zn(II) complexes with (E)-N-(pyridin-2-ylmethylene)arylamines that regulate tumour cell death by interacting with DNA.Activation of sulfonate ester based matrix metalloproteinase proinhibitors by hydrogen peroxideA prochelator activated by beta-secretase inhibits Abeta aggregation and suppresses copper-induced reactive oxygen species formation.A series of tripodal cysteine derivatives as water-soluble chelators that are highly selective for copper(I).A rationally designed small molecule for identifying an in vivo link between metal-amyloid-β complexes and the pathogenesis of Alzheimer's disease.Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stressHydrogen peroxide activated matrix metalloproteinase inhibitors: a prodrug approachRecent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's DiseaseDesign of small molecules that target metal-A{beta} species and regulate metal-induced A{beta} aggregation and neurotoxicity.Alzheimer's disease & metals: therapeutic opportunities.Misfolded proteins in Alzheimer's disease and type II diabetes.Tools of the trade: investigations into design strategies of small molecules to target components in Alzheimer's disease.A multifunctional, light-activated prochelator inhibits UVA-induced oxidative stressProchelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelationReactivity of diphenylpropynone derivatives toward metal-associated amyloid-β species.A boronate prochelator built on a triazole framework for peroxide-triggered tridentate metal bindingInsights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β speciesChelators for investigating zinc metalloneurochemistry.Clawing back: broadening the notion of metal chelators in medicineTris(2-pyridylmethyl)amine (TPA) as a membrane-permeable chelator for interception of biological mobile zinc.Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species.Metal ions, Alzheimer's disease and chelation therapy.Chelation therapy in Wilson's disease: from D-penicillamine to the design of selective bioinspired intracellular Cu(I) chelators.Recent discoveries on the functions of astrocytes in the copper homeostasis of the brain: a brief update.Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease.Sialic Acid Hydroxamate: A Potential Antioxidant and Inhibitor of Metal-Induced β-Amyloid Aggregates.Bimodal-hybrid heterocyclic amine targeting oxidative pathways and copper mis-regulation in Alzheimer's disease.Intracellular reduction/activation of a disulfide switch in thiosemicarbazone iron chelatorsDeveloping drugs targeting transition metal homeostasis.Development of bifunctional stilbene derivatives for targeting and modulating metal-amyloid-β species.Myricetin: a naturally occurring regulator of metal-induced amyloid-β aggregation and neurotoxicity.Transfer of Copper from an Amyloid to a Natural Copper-Carrier Peptide with a Specific Mediating Ligand.A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders.Bifunctional compounds for controlling metal-mediated aggregation of the aβ42 peptide.
P2860
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P2860
Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.
@ast
Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.
@en
type
label
Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.
@ast
Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.
@en
prefLabel
Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.
@ast
Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.
@en
P2860
P356
P1433
P1476
Minding metals: tailoring multifunctional chelating agents for neurodegenerative disease.
@en
P2093
Lissette R Perez
P2860
P304
P356
10.1039/B919237A
P407
P577
2009-12-17T00:00:00Z