Development of bifunctional stilbene derivatives for targeting and modulating metal-amyloid-β species.
about
Structure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer's disease.Synthesis and characterization of some water soluble Zn(II) complexes with (E)-N-(pyridin-2-ylmethylene)arylamines that regulate tumour cell death by interacting with DNA.Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease.Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β SpeciesSynthesis, Spectral Characterization, and Biochemical Evaluation of Antidiabetic Properties of a New Zinc-Diosmin Complex Studied in High Fat Diet Fed-Low Dose Streptozotocin Induced Experimental Type 2 Diabetes in Rats.Side-chain dynamics reveals transient association of Aβ(1-40) monomers with amyloid fibers.Reactivity of diphenylpropynone derivatives toward metal-associated amyloid-β species.Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β speciesAmyloid-β-neuropeptide interactions assessed by ion mobility-mass spectrometry.Zn(II) ions substantially perturb Cu(II) ion coordination in amyloid-β at physiological pH.Exploring the reactivity of flavonoid compounds with metal-associated amyloid-β species.The role of molecular simulations in the development of inhibitors of amyloid β-peptide aggregation for the treatment of Alzheimer's diseaseDesigning drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders.Biophysical studies of the amyloid β-peptide: interactions with metal ions and small molecules.Biological metals and metal-targeting compounds in major neurodegenerative diseases.Ultraviolet light triggers the conversion of Cu2+-bound Aβ42 aggregates into cytotoxic species in a copper chelation-independent manner.Bimodal-hybrid heterocyclic amine targeting oxidative pathways and copper mis-regulation in Alzheimer's disease.3-Hydroxy-4-pyridinone derivatives as metal ion and amyloid binding agents.Therapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalanine in phenylketonuria.The influence of counter ion and ligand methyl substitution on the solid-state structures and photophysical properties of mercury(II) complexes with (E)-N-(pyridin-2-ylmethylidene)arylamines.Development of multifunctional heterocyclic Schiff base as a potential metal chelator: a comprehensive spectroscopic approach towards drug discovery.Computer-assisted designed "selenoxy-chinolin": a new catalytic mechanism of the GPx-like cycle and inhibition of metal-free and metal-associated Aβ aggregation.The Role of Metal Binding in the Amyotrophic Lateral Sclerosis-Related Aggregation of Copper-Zinc Superoxide Dismutase.Insight into inhibition of the human amyloid beta protein precursor (APP: PDB ID ) using (E)-N-(pyridin-2-ylmethylene)arylamine (LR) models: structure elucidation of a family of ZnX2-LR complexes.Chelation-induced diradical formation as an approach to modulation of the amyloid-β aggregation pathway.Dual-function triazole-pyridine derivatives as inhibitors of metal-induced amyloid-β aggregationEffects of hydroxyl group variations on a flavonoid backbone toward modulation of metal-free and metal-induced amyloid-β aggregation
P2860
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P2860
Development of bifunctional stilbene derivatives for targeting and modulating metal-amyloid-β species.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Development of bifunctional st ...... ating metal-amyloid-β species.
@en
Development of bifunctional st ...... ating metal-amyloid-β species.
@nl
type
label
Development of bifunctional st ...... ating metal-amyloid-β species.
@en
Development of bifunctional st ...... ating metal-amyloid-β species.
@nl
prefLabel
Development of bifunctional st ...... ating metal-amyloid-β species.
@en
Development of bifunctional st ...... ating metal-amyloid-β species.
@nl
P2093
P2860
P356
P1433
P1476
Development of bifunctional st ...... lating metal-amyloid-β species
@en
P2093
Alaina S DeToma
Jeffrey W Kampf
Joseph J Braymer
Jung-Suk Choi
Mi Hee Lim
P2860
P304
10724-10734
P356
10.1021/IC2012205
P407
P577
2011-09-28T00:00:00Z