Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration - Wikidata - awgldk - TriplyDB

Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration

Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration

http://www.wikidata.org/entity/Q33840443

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Orai1 calcium channels in the vasculature Phospholipase C signaling and calcium influx Ca2+/calmodulin-dependent protein kinase II function in vascular remodelling Decreasing mitochondrial fission diminishes vascular smooth muscle cell migration and ameliorates intimal hyperplasia.Store-operated Ca2+ entry (SOCE) regulates melanoma proliferation and cell migration Store-operated calcium entry and diabetic complications Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers Mitochondria control store-operated Ca2+ entry through Na+ and redox signals.Regulation of cellular communication by signaling microdomains in the blood vessel wall.STIM1 translocation to the plasma membrane enhances intestinal epithelial restitution by inducing TRPC1-mediated Ca2+ signaling after wounding.Molecular mechanisms of spontaneous and directed mast cell motility.Role of molecular determinants of store-operated Ca(2+) entry (Orai1, phospholipase A2 group 6, and STIM1) in focal adhesion formation and cell migration.Platelet-derived growth factor maintains stored calcium through a nonclustering Orai1 mechanism but evokes clustering if the endoplasmic reticulum is stressed by store depletion Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels.A novel native store-operated calcium channel encoded by Orai3: selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast cancer cells.KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells.STIM1 regulates platelet-derived growth factor-induced migration and Ca2+ influx in human airway smooth muscle cells.Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia.Vascular balloon injury and intraluminal administration in rat carotid artery Orai1-mediated I (CRAC) is essential for neointima formation after vascular injury.STIM1 and Orai1: novel targets for vascular diseases?Key role for store-operated Ca2+ channels in activating gene expression in human airway bronchial epithelial cells.TRPC1 proteins confer PKC and phosphoinositol activation on native heteromeric TRPC1/C5 channels in vascular smooth muscle: comparative study of wild-type and TRPC1-/- mice.PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells.Enhanced store-operated Ca²+ entry and TRPC channel expression in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats.STIM and Orai proteins as novel targets for cancer therapy. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis.Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.Pathogenic role of store-operated and receptor-operated ca(2+) channels in pulmonary arterial hypertension.Airway smooth muscle STIM1 and Orai1 are upregulated in asthmatic mice and mediate PDGF-activated SOCE, CRAC currents, proliferation, and migration Orai3 is an estrogen receptor α-regulated Ca²⁺ channel that promotes tumorigenesis.Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle.Orai channel-mediated Ca2+ signals in vascular and airway smooth muscle.The polycystin complex mediates Wnt/Ca(2+) signalling.Emerging roles of Orai3 in pathophysiology.A polarized Ca2+, diacylglycerol and STIM1 signalling system regulates directed cell migration.Cholesterol modulates Orai1 channel function Cross-talk between calcium and protein kinase A in the regulation of cell migration.Unraveling STIM2 function.STIM/Orai signalling complexes in vascular smooth muscle.What role for store-operated Ca²⁺ entry in muscle?

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Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration

http://www.wikidata.org/entity/Q33840443

description

2010 nî lūn-bûn

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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Essential role for STIM1/Orai1 ...... nduced smooth muscle migration

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Essential role for STIM1/Orai1 ...... nduced smooth muscle migration

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Essential role for STIM1/Orai1 ...... nduced smooth muscle migration

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Essential role for STIM1/Orai1 ...... nduced smooth muscle migration

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Essential role for STIM1/Orai1 ...... nduced smooth muscle migration

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Essential role for STIM1/Orai1 ...... nduced smooth muscle migration

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AJPCELL.00325.2009

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American Journal of Physiology - Cell Physiology

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Essential role for STIM1/Orai1 ...... nduced smooth muscle migration

@en

P2093

David Jourd'heuil

http://www.w3.org/2001/XMLSchema#string

Harold A Singer

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Jonathan M Bisaillon

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José C Gonzalez-Cobos

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Katharine E Halligan

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Mohamed Trebak

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Rajender K Motiani

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Wael F Alzawahra

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P2860

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx

STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1

CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry

STIM1, an essential and conserved component of store-operated Ca2+ channel function

Inositol trisphosphate and calcium signalling

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

Activation transcription factor-4 induced by fibroblast growth factor-2 regulates vascular endothelial growth factor-A transcription in vascular smooth muscle cells and mediates intimal thickening in rat arteries following balloon injury

Calcium/calmodulin-dependent protein kinase II-delta isoform regulation of vascular smooth muscle cell proliferation

Molecular regulation of vascular smooth muscle cell differentiation in development and disease

Store-operated calcium channels

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C993-1005

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scholarly article

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10.1152/AJPCELL.00325.2009

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5

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298

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Margarida Barroso

Marie-Claude Potier

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2010-01-27T00:00:00Z

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41166046

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20107038

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2867390

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