about
The transcription factor p53: not a repressor, solely an activatorStochasticity of intranuclear biochemical reaction processes controls the final decision of cell fate associated with DNA damageCondition-specific target prediction from motifs and expression.A benchmark for chromatin binding measurements in live cells.Large-scale quality analysis of published ChIP-seq data.Microarray and ChIP-seq data analysis revealed changes in p53-mediated transcriptional regulation in Nutlin-3-treated U2OS cellsCSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest.Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms.All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis.p53 Isoforms: An Intracellular Microprocessor?A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection.Genome-wide recruitment to Polycomb-modified chromatin and activity regulation of the synovial sarcoma oncogene SYT-SSX2.High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activityProfiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damageCell context dependent p53 genome-wide binding patterns and enrichment at repeats.p53 binding to human genome: crowd control navigation in chromatin contextLevels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate.Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation.Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions.Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.Distinct p53 genomic binding patterns in normal and cancer-derived human cells.Phytometabolite Dehydroleucodine Induces Cell Cycle Arrest, Apoptosis, and DNA Damage in Human Astrocytoma Cells through p73/p53 RegulationThe Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition.3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation.Genome-wide studies of the transcriptional regulation by p53.Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiationp53 N-terminal phosphorylation: a defining layer of complex regulationLuffa echinata Roxb. Induced Apoptosis in Human Colon Cancer Cell (SW-480) in the Caspase-dependent Manner and Through a Mitochondrial Apoptosis PathwayAnti-apoptotic signaling as a cytoprotective mechanism in mammalian hibernation.Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses.HIPK family kinases bind and regulate the function of the CCR4-NOT complex.HIPK1 drives p53 activation to limit colorectal cancer cell growth.Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells.Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks.Genome-wide analysis of the p53 gene regulatory network in the developing mouse kidneyEliminating encephalitogenic T cells without undermining protective immunityPathway modulations and epigenetic alterations in ovarian tumorbiogenesis.MicroRNA-17-5p regulated apoptosis-related protein expression and radiosensitivity in oral squamous cell carcinoma caused by betel nut chewing.Deconstructing p53 transcriptional networks in tumor suppression.P53 and its molecular basis to chemoresistance in breast cancer.
P2860
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P2860
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Role of p53 serine 46 in p53 target gene regulation.
@ast
Role of p53 serine 46 in p53 target gene regulation.
@en
type
label
Role of p53 serine 46 in p53 target gene regulation.
@ast
Role of p53 serine 46 in p53 target gene regulation.
@en
prefLabel
Role of p53 serine 46 in p53 target gene regulation.
@ast
Role of p53 serine 46 in p53 target gene regulation.
@en
P2093
P2860
P1433
P1476
Role of p53 serine 46 in p53 target gene regulation.
@en
P2093
Bianca Gilbert
Eva Janssen-Megens
Hendrik G Stunnenberg
Leonie Smeenk
Marion Lohrum
Max Koeppel
P2860
P304
P356
10.1371/JOURNAL.PONE.0017574
P407
P577
2011-03-04T00:00:00Z