Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability
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Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cellsCharacterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinasePancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stressTwo novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinaseEvidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2Signaling by target of rapamycin proteins in cell growth controlIdentification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational controlIsolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinaseAssociation of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activationMechanism and regulation of eukaryotic protein synthesisThe histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acidsGenome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2pIfkA, a presumptive eIF2 alpha kinase of Dictyostelium, is required for proper timing of aggregation and regulation of mound sizeNutrient-sensing mechanisms across evolutionCrystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and MammalsCrystal structure of histidyl-tRNA synthetase from Escherichia coli complexed with histidyl-adenylateAromatic amino acid biosynthesis in the yeast Saccharomyces cerevisiae: a model system for the regulation of a eukaryotic biosynthetic pathway.Regulation of the transcription factor Gcn4 by Pho85 cyclin PCL5.Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression.Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain.Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2.Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.Complex formation by positive and negative translational regulators of GCN4.Posttranscriptional control of gene expression in yeast.Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells.Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control.Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae.Histidyl-tRNA synthetaseTwo heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertionEmbryonic Stem Cell Growth Factors Regulate eIF2α PhosphorylationAntiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA virusesMolecular cloning, characterization and localization of PfPK4, an eIF-2alpha kinase-related enzyme from the malarial parasite Plasmodium falciparumEffects of abiotic stress and crop management on cereal grain composition: implications for food quality and safety.Enhanced interaction between pseudokinase and kinase domains in Gcn2 stimulates eIF2α phosphorylation in starved cellsSelective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiaeIntegration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast.Inhibition of translation initiation by volatile anesthetics involves nutrient-sensitive GCN-independent and -dependent processes in yeast.Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.
P2860
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P2860
Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability
description
1989 nî lūn-bûn
@nan
1989 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Juxtaposition of domains homol ...... ion to amino acid availability
@ast
Juxtaposition of domains homol ...... ion to amino acid availability
@en
type
label
Juxtaposition of domains homol ...... ion to amino acid availability
@ast
Juxtaposition of domains homol ...... ion to amino acid availability
@en
prefLabel
Juxtaposition of domains homol ...... ion to amino acid availability
@ast
Juxtaposition of domains homol ...... ion to amino acid availability
@en
P2093
P2860
P356
P1476
Juxtaposition of domains homol ...... ion to amino acid availability
@en
P2093
P2860
P304
P356
10.1073/PNAS.86.12.4579
P407
P577
1989-06-01T00:00:00Z