Novel arylimidamides for treatment of visceral leishmaniasis. - Wikidata - awgldk - TriplyDB

Novel arylimidamides for treatment of visceral leishmaniasis.

Novel arylimidamides for treatment of visceral leishmaniasis.

http://www.wikidata.org/entity/Q33876693

about

Novel amidines and analogues as promising agents against intracellular parasites: a systematic review Structure of the HIV-1 Frameshift Site RNA Bound to a Small Molecule Inhibitor of Viral Replication In vitro and in vivo investigation of the efficacy of arylimidamide DB1831 and its mesylated salt form--DB1965--against Trypanosoma cruzi infection Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo Identification of new antileishmanial leads from hits obtained by high-throughput screening Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection.Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis.In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi A current perspective on leishmaniasis Arylimidamide DB766, a potential chemotherapeutic candidate for Chagas' disease treatment Studies on the antileishmanial mechanism of action of the arylimidamide DB766: azole interactions and role of CYP5122A1.Antileishmanial activity of a series of N²,N⁴-disubstituted quinazoline-2,4-diamines Bis-benzimidazole hits against Naegleria fowleri discovered with new high-throughput screens.Molecular factors governing inhibition of arylimidamides against Leishmania: conservative computational modeling to improve chemotherapies.The trypanocidal activity of amidine compounds does not correlate with their binding affinity to Trypanosoma cruzi kinetoplast DNA Experimental Chemotherapy for Chagas Disease: A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones.Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense.Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies In vitro and in vivo activities of dicationic diguanidino compounds against Echinococcus multilocularis metacestodes.In vitro effects of novel ruthenium complexes in Neospora caninum and Toxoplasma gondii tachyzoites.Di-cationic arylimidamides act against Neospora caninum tachyzoites by interference in membrane structure and nucleolar integrity and are active against challenge infection in mice.Novel compounds to combat trypanosomatid infections: a medicinal chemical perspective.In vitro efficacy of dicationic compounds and mefloquine enantiomers against Echinococcus multilocularis metacestodes Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery.Synthesis and pharmacological evaluation of mono-arylimidamides as antileishmanial agents Drug target identification in protozoan parasites.Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay.Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides.Structure-dependent binding of arylimidamides to the DNA minor groove.Real-time PCR to quantify Leishmania donovani in hamsters.Antileishmanial Efficacy and Pharmacokinetics of DB766-azole Combinations.Unveiling the effects of berenil, a DNA-binding drug, on Trypanosoma cruzi: implications for kDNA ultrastructure and replication.Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries.The adaptive potential of a survival artist: characterization of the in vitro interactions of Toxoplasma gondii tachyzoites with di-cationic compounds in human fibroblast cell cultures.In vitro effects of arylimidamides against Besnoitia besnoiti infection in Vero cells.

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P2860

Novel arylimidamides for treatment of visceral leishmaniasis.

http://www.wikidata.org/entity/Q33876693

description

2010 nî lūn-bûn

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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2010 թվականի ապրիլին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Novel arylimidamides for treatment of visceral leishmaniasis.

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Novel arylimidamides for treatment of visceral leishmaniasis.

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Novel arylimidamides for treatment of visceral leishmaniasis.

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Novel arylimidamides for treatment of visceral leishmaniasis.

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Novel arylimidamides for treatment of visceral leishmaniasis.

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Novel arylimidamides for treatment of visceral leishmaniasis.

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Antimicrobial Agents and Chemotherapy

P1476

Novel arylimidamides for treatment of visceral leishmaniasis.

@en

P2093

Anuradha Srivastava

http://www.w3.org/2001/XMLSchema#string

Chad E Stephens

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David W Boykin

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Ed Riccio

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J Mark Sweat

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James Edwin Hall

http://www.w3.org/2001/XMLSchema#string

Karl A Werbovetz

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Manoj Munde

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Michael Zhuo Wang

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Qiang Liu

http://www.w3.org/2001/XMLSchema#string

P2860

Treatment options for visceral leishmaniasis: a systematic review of clinical studies done in India, 1980-2004

Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?

Clinical spectrum of Leishmaniasis.

pH homeostasis in Leishmania donovani amastigotes and promastigotes.

The Ames Salmonella/microsome mutagenicity assay.

Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion.

Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.

Oral miltefosine for Indian visceral leishmaniasis.

Physicochemical profiling (solubility, permeability and charge state).

Sitamaquine (GlaxoSmithKline/Walter Reed Army Institute).

P304

2507-2516

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scholarly article

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10.1128/AAC.00250-10

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P433

6

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P478

54

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Rentala Madhubala

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2010-04-05T00:00:00Z

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20368397

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visceral leishmaniasis

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2876428

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