Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain.
about
SH2B1beta adaptor is a key enhancer of RET tyrosine kinase signalingKinase activation through dimerization by human SH2-BSH2-B is required for both male and female reproductionDifferential binding to and regulation of JAK2 by the SH2 domain and N-terminal region of SH2-bbetaRegulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteinsRegulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, LnkSH2B1 and IRSp53 proteins promote the formation of dendrites and dendritic branchesInteraction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activationFour PSM/SH2-B alternative splice variants and their differential roles in mitogenesis.Interplay between cell migration and neurite outgrowth determines SH2B1β-enhanced neurite regeneration of differentiated PC12 cellsSH2B1 regulation of energy balance, body weight, and glucose metabolism.Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14.SH2-B family members differentially regulate JAK family tyrosine kinases.YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling.Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growthIdentification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signalingAdapter protein SH2B1beta binds filamin A to regulate prolactin-dependent cytoskeletal reorganization and cell motility.Identification of SH2B1β as a focal adhesion protein that regulates focal adhesion size and number.Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.Insulin-like growth factor 1 alleviates high-fat diet-induced myocardial contractile dysfunction: role of insulin signaling and mitochondrial function.SH2B1beta (SH2-Bbeta) enhances expression of a subset of nerve growth factor-regulated genes important for neuronal differentiation including genes encoding urokinase plasminogen activator receptor and matrix metalloproteinase 3/10.Adapter protein SH2B1beta cross-links actin filaments and regulates actin cytoskeletonNucleocytoplasmic shuttling of the adapter protein SH2B1beta (SH2-Bbeta) is required for nerve growth factor (NGF)-dependent neurite outgrowth and enhancement of expression of a subset of NGF-responsive genesSH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins.Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intoleranceSH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin.SH2B1 in β-cells regulates glucose metabolism by promoting β-cell survival and islet expansion.SH2B1 in β-cells promotes insulin expression and glucose metabolism in mice.The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis.Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active statePTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance.SH2-B is a positive regulator of nerve growth factor-mediated activation of the Akt/Forkhead pathway in PC12 cells.Adapter protein SH2-B beta undergoes nucleocytoplasmic shuttling: implications for nerve growth factor induction of neuronal differentiation.The APS adapter protein couples the insulin receptor to the phosphorylation of c-Cbl and facilitates ligand-stimulated ubiquitination of the insulin receptor.SH2-B is required for growth hormone-induced actin reorganization.Phosphorylation of the Unique C-terminal Tail of the Alpha Isoform of the Scaffold Protein SH2B1 Controls the Ability of SH2B1alpha to Enhance Nerve Growth Factor Function.Diversity in peptide recognition by the SH2 domain of SH2B1.The Effect of SH2B1 Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus.
P2860
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P2860
Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain.
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Alternative splicing, gene loc ...... nsulin receptor kinase domain.
@ast
Alternative splicing, gene loc ...... nsulin receptor kinase domain.
@en
type
label
Alternative splicing, gene loc ...... nsulin receptor kinase domain.
@ast
Alternative splicing, gene loc ...... nsulin receptor kinase domain.
@en
prefLabel
Alternative splicing, gene loc ...... nsulin receptor kinase domain.
@ast
Alternative splicing, gene loc ...... nsulin receptor kinase domain.
@en
P2093
P356
P1433
P1476
Alternative splicing, gene loc ...... insulin receptor kinase domain
@en
P2093
P2888
P304
P356
10.1007/S003359901183
P577
1999-12-01T00:00:00Z