Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance
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Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advancesSH2B1beta adaptor is a key enhancer of RET tyrosine kinase signalingKinase activation through dimerization by human SH2-BRegulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteinsEnergy metabolism in the liverRegulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, LnkReceptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2Laboratory mouse models for the human genome-wide associationsStructural basis for inhibition of the insulin receptor by the adaptor protein Grb14The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cellsThe SH2B gene is associated with serum leptin and body fat in normal female twins.SH2B regulation of growth, metabolism, and longevity in both insects and mammals.Studies of metabolic phenotypic correlates of 15 obesity associated gene variantsSH2B1 regulation of energy balance, body weight, and glucose metabolism.Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1Critical role of the Src homology 2 (SH2) domain of neuronal SH2B1 in the regulation of body weight and glucose homeostasis in mice.The adaptor protein SH2B1β reduces hydrogen peroxide-induced cell death in PC12 cells and hippocampal neurons.Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signalingScreening for coding variants in FTO and SH2B1 genes in Chinese patients with obesity.Phosphorylation controls a dual-function polybasic nuclear localization sequence in the adapter protein SH2B1β to regulate its cellular function and distributionNew function of the adaptor protein SH2B1 in brain-derived neurotrophic factor-induced neurite outgrowthHepatic SH2B1 and SH2B2 regulate liver lipid metabolism and VLDL secretion in miceAdapter protein SH2B1beta binds filamin A to regulate prolactin-dependent cytoskeletal reorganization and cell motility.Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.Genes and lifestyle factors in obesity: results from 12,462 subjects from MONICA/KORA.Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses.Adapter protein SH2-Bbeta stimulates actin-based motility of Listeria monocytogenes in a vasodilator-stimulated phosphoprotein (VASP)-dependent fashion.Grb10 and Grb14: enigmatic regulators of insulin action--and more?Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource.NF-κB–inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon actionAdapter protein SH2B1beta cross-links actin filaments and regulates actin cytoskeletonSH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins.Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasisSH2B1 in β-cells regulates glucose metabolism by promoting β-cell survival and islet expansion.SH2B1 in β-cells promotes insulin expression and glucose metabolism in mice.Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy.The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis.Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active stateRecent advances of adapter proteins in the regulation of heart diseases.Evidence for Association between SH2B1 Gene Variants and Glycated Hemoglobin in Nondiabetic European American Young Adults: The Add Health Study
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Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on September 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Disruption of the SH2-B gene c ...... stance and glucose intolerance
@en
Disruption of the SH2-B gene c ...... tance and glucose intolerance.
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type
label
Disruption of the SH2-B gene c ...... stance and glucose intolerance
@en
Disruption of the SH2-B gene c ...... tance and glucose intolerance.
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prefLabel
Disruption of the SH2-B gene c ...... stance and glucose intolerance
@en
Disruption of the SH2-B gene c ...... tance and glucose intolerance.
@nl
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P1476
Disruption of the SH2-B gene c ...... stance and glucose intolerance
@en
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Chaojun Duan
Hongyan Yang
Liangyou Rui
Morris F White
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P304
P356
10.1128/MCB.24.17.7435-7443.2004
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2004-09-01T00:00:00Z