DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical-protein interactome - Wikidata - awgldk - TriplyDB

DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical-protein interactome

DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical-protein interactome

http://www.wikidata.org/entity/Q33894409

about

Genome-scale screening of drug-target associations relevant to Ki using a chemogenomics approach 'RE:fine drugs': an interactive dashboard to access drug repurposing opportunities Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review Implications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical function Plumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cells Systematic drug repositioning based on clinical side-effects Prediction of chemical-protein interactions network with weighted network-based inference method Prediction of drug-target interactions for drug repositioning only based on genomic expression similarity Towards structural systems pharmacology to study complex diseases and personalized medicine Construction of drug network based on side effects and its application for drug repositioning Drug repositioning for diabetes based on 'omics' data mining Hypothyroidism Side Effect in Patients Treated with Sunitinib or Sorafenib: Clinical and Structural Analyses Drug Repositioning for Alzheimer's Disease Based on Systematic 'omics' Data Mining Network-based in silico drug efficacy screening DPDR-CPI, a server that predicts Drug Positioning and Drug Repositioning via Chemical-Protein Interactome In Silico target fishing: addressing a "Big Data" problem by ligand-based similarity rankings with data fusion.Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases.The polypharmacology browser: a web-based multi-fingerprint target prediction tool using ChEMBL bioactivity data DDI-CPI, a server that predicts drug-drug interactions through implementing the chemical-protein interactome.Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal study.Drug repositioning for orphan genetic diseases through Conserved Anticoexpressed Gene Clusters (CAGCs)A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver.TargetNet: a web service for predicting potential drug-target interaction profiling via multi-target SAR models.ProBiS-2012: web server and web services for detection of structurally similar binding sites in proteins.Comprehensive prediction of drug-protein interactions and side effects for the human proteome.Opportunities for Web-based Drug Repositioning: Searching for Potential Antihypertensive Agents with Hypotension Adverse Events Discovery of the molecular mechanisms of the novel chalcone-based Magnaporthe oryzae inhibitor C1 using transcriptomic profiling and co-expression network analysis.Differences in reproductive toxicology between alopecia drugs: an analysis on adverse events among female and male cases.Network-based drug repositioning.Contributions from emerging transcriptomics technologies and computational strategies for drug discovery.Targeting molecular networks for drug research Polypharmacology in Drug Development: A Minireview of Current Technologies.Using reverse docking for target identification and its applications for drug discovery.Toxicological Differences Between NMDA Receptor Antagonists and Cholinesterase Inhibitors.SDTNBI: an integrated network and chemoinformatics tool for systematic prediction of drug-target interactions and drug repositioning.Towards drug repositioning: a unified computational framework for integrating multiple aspects of drug similarity and disease similarity.Targets of drugs are generally, and targets of drugs having side effects are specifically good spreaders of human interactome perturbations Identification of a Potential Target of Capsaicin by Computational Target Fishing.System Pharmacology-Based Dissection of the Synergistic Mechanism of Huangqi and Huanglian for Diabetes Mellitus.Potential antitumor mechanisms of phenothiazine drugs.

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DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical-protein interactome

http://www.wikidata.org/entity/Q33894409

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2011 nî lūn-bûn

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2011年の論文

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Nucleic Acids Research

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Heng Luo

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Huang Zhu

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Jian Chen

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Kejian Wang

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Leming Shi

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Lin He

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Lun Yang

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Mike Mikailov

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P2860

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

Predicting new molecular targets for known drugs

DrugBank: a knowledgebase for drugs, drug actions and drug targets

DOCK 4.0: Search strategies for automated molecular docking of flexible molecule databases

Harvesting candidate genes responsible for serious adverse drug reactions from a chemical-protein interactome

Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine

Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets

Binding of protein kinase inhibitors to synapsin I inferred from pair-wise binding site similarity measurements

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10.1093/NAR/GKR299

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Web Server issue

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39

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2011-05-10T00:00:00Z

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51113420

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21558322

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3125745

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