Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase
about
Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cellsEffective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.R-RAS2 overexpression in tumors of the human central nervous system.Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.Transcriptional and Translational Downregulation of Thioredoxin Interacting Protein Is Required for Metabolic Reprogramming during G(1).Identification of mutations in distinct regions of p85 alpha in urothelial cancer.PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.p85β phosphoinositide 3-kinase subunit regulates tumor progressionIrs2 inactivation suppresses tumor progression in Pten+/- mice.Immunological considerations of modern animal models of malignant primary brain tumors.Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking.Phosphorylation of ErbB4 on Tyr1056 is critical for inhibition of colony formation by prostate tumor cell lines.The PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells.p85β increases phosphoinositide 3-kinase activity and accelerates tumor progression.The PI3K Pathway in Human Disease.PI3K in cancer: its structure, activation modes and role in shaping tumor microenvironment.p85 protein expression is associated with poor survival in HER2-positive patients with advanced breast cancer treated with trastuzumab.
P2860
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P2860
Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase
description
2005 nî lūn-bûn
@nan
2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Modulation of epithelial neopl ...... s of phosphoinositide 3-kinase
@ast
Modulation of epithelial neopl ...... s of phosphoinositide 3-kinase
@en
type
label
Modulation of epithelial neopl ...... s of phosphoinositide 3-kinase
@ast
Modulation of epithelial neopl ...... s of phosphoinositide 3-kinase
@en
prefLabel
Modulation of epithelial neopl ...... s of phosphoinositide 3-kinase
@ast
Modulation of epithelial neopl ...... s of phosphoinositide 3-kinase
@en
P2093
P2860
P356
P1476
Modulation of epithelial neopl ...... s of phosphoinositide 3-kinase
@en
P2093
Benjamin G Neel
Cassandra L Sobkiw
Eyoung Shin
Fionnuala O'Connell
John M Watt
Nicole M Logsdon
Ronald A Depinho
Sabina Signoretti
P2860
P304
10238-10243
P356
10.1073/PNAS.0504378102
P407
P577
2005-07-08T00:00:00Z