Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN. - Wikidata - awgldk - TriplyDB

Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.

Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.

http://www.wikidata.org/entity/Q34882666

about

Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors The PI3K pathway as drug target in human cancer Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β-Cell Dysfunction Insulin receptor signaling in normal and insulin-resistant states Involvement of the IRE1α-XBP1 pathway and XBP1s-dependent transcriptional reprogramming in metabolic diseases The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase.Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.Mild electrical stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling.Selective regulation of axonal growth from developing hippocampal neurons by tumor necrosis factor superfamily member APRIL Cytokine Receptor Endocytosis: New Kinase Activity-Dependent and -Independent Roles of PI3K.Impact of rs361072 in the phosphoinositide 3-kinase p110beta gene on whole-body glucose metabolism and subunit protein expression in skeletal muscle PIP3 but not PIP2 increases GLUT4 surface expression and glucose metabolism mediated by AKT/PKCζ/λ phosphorylation in 3T3L1 adipocytes Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway.Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.TAT-protein blockade during ischemia/reperfusion reveals critical role for p85 PI3K-PTEN interaction in cardiomyocyte injury.Phosphoinositide 3-kinase signaling in retinal rod photoreceptors.The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.Hydrogen sulfide and L-cysteine increase phosphatidylinositol 3,4,5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)/serine/threonine protein kin Chronic Dietary Administration of the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG) Inhibits the Growth of Implanted Ehrlich's Ascites Tumor in Mice Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.p110α Hot Spot Mutations E545K and H1047R Exert Metabolic Reprogramming Independently of p110α Kinase Activity.The phosphoinositide 3-kinase signaling pathway in normal and malignant B cells: activation mechanisms, regulation and impact on cellular functions.Role of phosphoinositide 3-kinase signaling in autoimmunity.Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2.Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease.Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer.Adipose tissue insulin sensitivity and macrophage recruitment: Does PI3K pick the pathway?Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemia Pioglitazone does not improve insulin signaling in mice with GH over-expression.Resistin competes with lipopolysaccharide for binding to toll-like receptor 4 Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations.Regulation of epithelial-mesenchymal transition in palatal fusion.Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.Human placental lactogen induces CYP2E1 expression via PI 3-kinase pathway in female human hepatocytes.BRD7, a tumor suppressor, interacts with p85α and regulates PI3K activity.

P2860

Q24305218-E1F7523D-10E6-467E-A560-FE07F092711A Q24632283-7CF7272B-5726-47E1-A0D3-F6EB88CD6B39 Q26773657-A6D492D1-DEBB-4467-9FF7-317850DC7476 Q26800081-3CF98D49-C5DB-4F60-9B05-190EE59AF686 Q26823171-66F62B59-A12F-4A5C-A775-E11DC4B88251 Q27015015-80F2D671-7055-4245-85A8-7A7AE5D66A27 Q27851848-229D89FB-B377-4028-9566-C8DD78303168 Q30156937-7CBE7CA1-ADD7-4454-9763-A1F7BDF6516E Q30481572-093E5C04-6D5E-4098-A99D-AECB2C3ABC16 Q30856517-8D81C663-CB62-4C55-A10D-42683B81B962 Q33559757-243B7D1D-1D89-4C75-90A0-2A43BA1D17F8 Q33619529-D9C492E7-CEB0-4298-AD11-7E54E7F0FF2E Q33750663-D24428EF-2A76-48A1-B09F-3F18E884D8DB Q33777732-2AD0DE5D-91F3-4BE8-8CC9-A753ACD7518F Q33865202-E8C8DC20-58E2-48F1-B85D-FD00A0DBBF1B Q34787325-87BC63D8-B80F-4D69-9B42-874562AC16E9 Q35131032-FE7F8EAC-989D-47AA-A2D4-22021797A9C6 Q35154138-54F65526-D0CC-4189-B335-7298394126DE Q35221193-5AB17946-8612-4ECB-B227-085FEB3DCCB5 Q35479152-6B4FA774-B127-4B21-BDB6-672BA50F4D1C Q35562685-2604A6B2-66B9-43EE-BC7D-E6FCD0D8BE4F Q35681147-6F6C16D2-2501-4EBA-83AC-54A62A363689 Q35808718-9C125324-B55F-4ECD-BD65-ED6A61509D71 Q35856767-61F92A8B-5280-42E5-AB51-6338E88EE30F Q36033370-7C676C9A-EECC-4303-B793-9D438802ED8A Q36150234-3EC79FE1-C2C4-4CA2-9466-CD6032A69CB5 Q36922987-AE6D77D5-46A2-4D13-8510-4718DD772D6B Q37008854-F9FBB638-79C9-4775-9304-D606AD72D729 Q37078025-F06C69FD-1746-4511-82E5-CA909F07E0FA Q37094068-01F4A906-21B8-4AA2-8312-A96806328E73 Q37103052-6B49EA60-0260-4251-A85C-F7C3B4968266 Q37129090-5E4EAF4E-9257-41C3-8A42-2E4FF669ACDC Q37201991-1427BA2E-4C3C-4341-80CD-E1558D0B70C7 Q37262649-F3065822-CA59-4A47-BACF-133012206B9A Q37310966-373C0F2C-FDF7-4C3E-9F87-9DC62A2A3920 Q37351598-5575F43F-0A59-482C-82A2-C656B6E39FE9 Q37398452-64FE8874-36C5-475D-B957-97A9E13B06D0 Q37418266-02018A38-66D3-446B-9CD9-3DCBCA4DAF7B Q37663399-0A193E0A-471F-43A2-BB50-64C52B3E4909 Q37731459-37AB27EF-391D-4BF7-A7F0-8CCCC62A2766

P2860

Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.

http://www.wikidata.org/entity/Q34882666

description

2006 nî lūn-bûn

@nan

2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Phosphoinositide 3-kinase regu ...... a positive regulation of PTEN.

@ast

Phosphoinositide 3-kinase regu ...... a positive regulation of PTEN.

@en

Phosphoinositide 3-kinase regu ...... a positive regulation of PTEN.

@nl

type

label

Phosphoinositide 3-kinase regu ...... a positive regulation of PTEN.

@ast

Phosphoinositide 3-kinase regu ...... a positive regulation of PTEN.

@en

Phosphoinositide 3-kinase regu ...... a positive regulation of PTEN.

@nl

prefLabel

Phosphoinositide 3-kinase regu ...... a positive regulation of PTEN.

@ast

Phosphoinositide 3-kinase regu ...... a positive regulation of PTEN.

@en

Phosphoinositide 3-kinase regu ...... a positive regulation of PTEN.

@nl

P1433

Q34882666-6131C4D5-31B6-4C6E-91C5-C01DF70B001C

P1476

Q34882666-A13956CD-7268-42B2-B0F5-ECB72426E340

P2093

Q34882666-4CE03D68-94B6-42FB-924B-2FB0E8C3472A

Q34882666-972A65AA-2A2A-4D93-9684-39D678C9F3A6

Q34882666-9B999788-010E-4FDA-BC7F-98FC586FFBE8

Q34882666-A45B5353-89B3-490D-A287-BCB339C47DAE

P2860

Q34882666-06664F92-EBCA-438B-80FA-BD73E52A5BDA

Q34882666-0857A2E7-AFAF-43F5-8DE6-1A89944D7289

Q34882666-0950D419-2F9B-49B2-AEC3-AEA2EF681906

Q34882666-0D7CB20A-2EA6-4D73-A910-5F92BACD620A

Q34882666-107FAC7C-32C3-4285-A9F3-E7FDB32FD133

Q34882666-185BF3AF-664E-4BF8-B1ED-8ADF177C50ED

Q34882666-25186D06-D5A3-41FE-A8FB-DA5D2062512E

Q34882666-2C08DBBC-0E05-4CA6-BC78-489D031F2152

Q34882666-2C3BC102-C685-470B-9D65-8E819A618E72

Q34882666-3D1D296B-9C04-4016-AC17-FD567A35CCBC

P304

Q34882666-7F6FC1D9-F0FA-43EE-A77B-7336A2AF1B4F

P31

Q34882666-12742CD0-59DE-4E8C-985C-F080FA25B85D

P356

Q34882666-D113B58E-87DE-4BF1-9C7A-0522FD204025

P407

Q34882666-D6546500-0276-4021-A547-DE2C941A82D4

P433

Q34882666-2E63008C-9702-4FAE-A6EA-89C2A36F9B92

P478

Q34882666-A4530753-5FF4-441B-B7D2-CA36A0B1099D

P50

Q34882666-1225D54F-0B00-4A8D-80ED-F66E0A1B7668

Q34882666-B2712489-A077-4B00-8115-6852C8C7C8BF

Q34882666-BE54EAA7-EA08-4B4D-85CD-6C0332EF9614

P577

Q34882666-BF829402-D2F9-4E4A-826F-58C1F39E156F

P5875

Q34882666-E756DBA7-CCBC-4117-BBEA-8EADD92F53FA

P698

Q34882666-2AEFF3AC-21E6-436F-8C68-19E9E4F3FF86

P921

Q34882666-1A257B9E-8213-44AB-AC7F-CB1F3CA01AC3

P932

Q34882666-E5E49597-DFD1-42AE-B5BF-10D2A4A2ABCB

P356

PNAS.0604628103

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Phosphoinositide 3-kinase regu ...... a positive regulation of PTEN.

@en

P2093

Cullen M Taniguchi

http://www.w3.org/2001/XMLSchema#string

Ji Luo

http://www.w3.org/2001/XMLSchema#string

Tatsuya Kondo

http://www.w3.org/2001/XMLSchema#string

Thien T Tran

http://www.w3.org/2001/XMLSchema#string

P2860

Insulin signalling and the regulation of glucose and lipid metabolism

Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

Direct identification of PTEN phosphorylation sites

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

Critical nodes in signalling pathways: insights into insulin action

P304

12093-12097

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0604628103

http://www.w3.org/2001/XMLSchema#string

P407

P433

32

http://www.w3.org/2001/XMLSchema#string

P478

103

http://www.w3.org/2001/XMLSchema#string

P50

Lewis C. Cantley

P577

2006-07-31T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6907064

http://www.w3.org/2001/XMLSchema#string

P698

16880400

http://www.w3.org/2001/XMLSchema#string

P921

P932

1524929

http://www.w3.org/2001/XMLSchema#string