Partial impairment of cytokine responses in Tyk2-deficient mice.
about
The Janus kinases (Jaks)SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptorJanus kinases in immune cell signalingTYK2 is a key regulator of the surveillance of B lymphoid tumorsBasal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motifTpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondiiSelectivity and therapeutic inhibition of kinases: to be or not to be?Therapeutic targeting of Janus kinasesTyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytesA natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunityRole of type I interferons in the activation of autoreactive B cellsInflammatory pathways of importance for management of inflammatory bowel diseaseInducible, dose-adjustable and time-restricted reconstitution of STAT1 deficiency in vivoEnabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitorSignaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha componentConstitutive type I interferon modulates homeostatic balance through tonic signalingHuman TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndromeInterleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR)Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression.A novel transactivating factor that regulates interferon-gamma-dependent gene expressionTyrosine kinase inhibitors for the treatment of rheumatoid arthritisTYK2 kinase activity is required for functional type I interferon responses in vivoKinase Inactive Tyrosine Kinase (Tyk2) Supports Differentiation of Brown Fat Cells.A time- and dose-dependent STAT1 expression system.Interleukin-10 suppression of myeloid cell activation--a continuing puzzle.Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes.Octamer-binding factor 6 (Oct-6/Pou3f1) is induced by interferon and contributes to dsRNA-mediated transcriptional responses.STAT1β is not dominant negative and is capable of contributing to gamma interferon-dependent innate immunity.Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27The molecular regulation of Janus kinase (JAK) activationInterferons, signal transduction pathways, and the central nervous system.Role of Tyk-2 in Th9 and Th17 cells in allergic asthma.Impact of microbes on autoimmune diseases.SH2-B family members differentially regulate JAK family tyrosine kinases.Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation.Jak3-independent trafficking of the common gamma chain receptor subunit: chaperone function of Jaks revisited.Lipoteichoic acid-induced nitric oxide production depends on the activation of platelet-activating factor receptor and Jak2.The arrival of JAK inhibitors: advancing the treatment of immune and hematologic disorders.Jak3, severe combined immunodeficiency, and a new class of immunosuppressive drugs.A single nucleotide polymorphism in Tyk2 controls susceptibility to experimental allergic encephalomyelitis
P2860
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P2860
Partial impairment of cytokine responses in Tyk2-deficient mice.
description
2000 nî lūn-bûn
@nan
2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Partial impairment of cytokine responses in Tyk2-deficient mice.
@ast
Partial impairment of cytokine responses in Tyk2-deficient mice.
@en
type
label
Partial impairment of cytokine responses in Tyk2-deficient mice.
@ast
Partial impairment of cytokine responses in Tyk2-deficient mice.
@en
prefLabel
Partial impairment of cytokine responses in Tyk2-deficient mice.
@ast
Partial impairment of cytokine responses in Tyk2-deficient mice.
@en
P2093
P1433
P1476
Partial impairment of cytokine responses in Tyk2-deficient mice.
@en
P2093
Karaghiosoff M
Neubauer H
P304
P356
10.1016/S1074-7613(00)00054-6
P407
P577
2000-10-01T00:00:00Z