A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. - Wikidata - awgldk - TriplyDB

A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.

A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.

http://www.wikidata.org/entity/Q33934228

about

Activated Ras as a Therapeutic Target: Constraints on Directly Targeting Ras Isoforms and Wild-Type versus Mutated Proteins Small-molecule inhibitors of the Rce1p CaaX protease Chemical inhibition of CaaX protease activity disrupts yeast Ras localization.Ras oncogenes: split personalities Targeting protein lipidation in disease Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase.A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells.Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease Antimetabolites and cancer: emerging data with a focus on antifolates.Protein post-translational modifications: In silico prediction tools and molecular modeling.Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis Alterations in molecular chaperones and eIF2alpha during lung endothelial cell apoptosis Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms.Therapeutic intervention based on protein prenylation and associated modifications An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo.Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization Development of synthetic lethality anticancer therapeutics.Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis.Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators.Drugging the undruggable RAS: Mission possible?A role for Rac3 GTPase in the regulation of autophagy.Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase.The isoprenoid substrate specificity of isoprenylcysteine carboxylmethyltransferase: development of novel inhibitors.Synthesis of desthio prenylcysteine analogs: sulfur is important for biological activity Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase.Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease.Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease.Role of transmethylation reactions in alcoholic liver disease.Solid-phase synthesis of prenylcysteine analogs Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression.Ras acylation, compartmentalization and signaling nanoclusters (Review).Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration.Heterologous expression studies of Saccharomyces cerevisiae reveal two distinct trypanosomatid CaaX protease activities and identify their potential targets.A RAS renaissance: emerging targeted therapies for KRAS-mutated non-small cell lung cancer.Regulating the regulator: post-translational modification of RAS Rho GTPase signaling in the development of colorectal cancer.Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?Current status of the development of Ras inhibitors.The renewed battle against RAS-mutant cancers.Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism.

P2860

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P2860

A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.

http://www.wikidata.org/entity/Q33934228

description

2005 nî lūn-bûn

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2005 թուականի Մարտին հրատարակուած գիտական յօդուած

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2005 թվականի մարտին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

A small-molecule inhibitor of ...... umor activity in cancer cells.

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A small-molecule inhibitor of ...... umor activity in cancer cells.

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A small-molecule inhibitor of ...... umor activity in cancer cells.

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A small-molecule inhibitor of ...... umor activity in cancer cells.

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P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

A small-molecule inhibitor of ...... tumor activity in cancer cells

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P2093

Ann M Winter-Vann

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David M Gooden

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Eric J Toone

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John D York

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June dela Cruz

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Martin O Bergo

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Patrick J Casey

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Rudi A Baron

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Waihay Wong

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P2860

Cloning and characterization of a mammalian prenyl protein-specific protease

Isoprenylcysteine carboxyl methyltransferase deficiency in mice

Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum

Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases

Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate

A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation

Cell signaling by receptor tyrosine kinases

The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins.

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4336-4341

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scholarly article

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10.1073/PNAS.0408107102

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12

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102

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Stephen G. Young

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2005-03-01T00:00:00Z

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7949963

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15784746

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555472

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