Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
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Human CD57+ germinal center-T cells are the major helpers for GC-B cells and induce class switch recombinationActivation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificitiesAID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization.Somatic hypermutation of the AID transgene in B and non-B cellsThe structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNaseExpression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genesRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationEtoposide induces nuclear re-localisation of AIDHepatitis C Virus (HCV)-Induced Immunoglobulin Hypermutation Reduces the Affinity and Neutralizing Activities of Antibodies against HCV Envelope ProteinAID targeting is dependent on RNA polymerase II pausing.AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversificationActivation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogrammingMsh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombinationIntracellular localization of differentially regulated RNA-specific adenosine deaminase isoforms in inflammationGenome-wide somatic hypermutation.Complex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cellsA target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expressionCorrelation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.Biased use of the IGHV4 family and evidence for antigen selection in Chlamydophila psittaci-negative ocular adnexal extranodal marginal zone lymphomas.Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells.Mimicking the germinal center reaction in hybridoma cells to isolate temperature-selective anti-PEG antibodies.MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes.Negative regulation of activation-induced cytidine deaminase in B cellsMutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand breakSecondary B cell receptor diversification is necessary for T cell mediated neuro-inflammation during experimental autoimmune encephalomyelitis.AID and mismatch repair in antibody diversification.Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).Accessibility control and machinery of immunoglobulin class switch recombination.Class-switch recombination: after the dawn of AID.What role for AID: mutator, or assembler of the immunoglobulin mutasome?DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation.Genomic uracil homeostasis during normal B cell maturation and loss of this balance during B cell cancer development.Recombinase-mediated cassette exchange as a novel method to study somatic hypermutation in Ramos cellsProduction of secretory immunoglobulin A against Shiga toxin-binding subunits in mice by mucosal immunization.Immunoglobulin gene conversion: insights from bursal B cells and the DT40 cell line.UNG shapes the specificity of AID-induced somatic hypermutation.Single-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID.The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks.
P2860
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P2860
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
description
2002 nî lūn-bûn
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2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
@ast
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
@en
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
@nl
type
label
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
@ast
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
@en
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
@nl
prefLabel
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
@ast
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
@en
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
@nl
P2093
P356
P1433
P1476
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas
@en
P2093
Alberto Martin
Caroline J Woo
Manxia Fan
Marc J Shulman
Matthew D Scharff
Philip D Bardwell
P2888
P356
10.1038/NATURE714
P407
P577
2002-02-14T00:00:00Z
P5875
P6179
1045191175