General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility.
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4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABA(A) receptorHigh-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analoguesPropofol suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channelsPropofol: a review of its role in pediatric anesthesia and sedationGeneral anesthesia mediated by effects on ion channelsSpike avalanches exhibit universal dynamics across the sleep-wake cycleA Unitary Anesthetic Binding Site at High ResolutionMethionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anestheticsChanges in effective connectivity by propofol sedation4-Chloropropofol enhances chloride currents in human hyperekplexic and artificial mutated glycine receptors.A residue in loop 9 of the beta2-subunit stabilizes the closed state of the GABAA receptor.Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.Anaesthetic mechanisms: update on the challenge of unravelling the mystery of anaesthesia.m-Azipropofol (AziPm) a photoactive analogue of the intravenous general anesthetic propofolMultiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol.Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation.Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog.Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics.Anesthetic drug development: Novel drugs and new approaches.Discovery of a novel general anesthetic chemotype using high-throughput screening.The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolaseSynaptic-type α1β2γ2L GABAA receptors produce large persistent currents in the presence of ambient GABA and anesthetic drugs.An allosteric coagonist model for propofol effects on α1β2γ2L γ-aminobutyric acid type A receptors.Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors.Mechanisms of neurosteroid interactions with GABA(A) receptors.In vivo activation of azipropofol prolongs anesthesia and reveals synaptic targets.p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol.HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.Macroscopic and macromolecular specificity of alkylphenol anesthetics for neuronal substrates.Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain.Role for the propofol hydroxyl in anesthetic protein target molecular recognition.Is a new paradigm needed to explain how inhaled anesthetics produce immobility?Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channelsA Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of γ-Aminobutyric Acid, Type A (GABAA), Receptor Subunit Binding Selectivity in Synaptosomes.Assessment of homology templates and an anesthetic binding site within the γ-aminobutyric acid receptor.Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1.Guilty, or not guilty?: a short story of propofol abuse.Using anesthetics and analgesics in experimental traumatic brain injury
P2860
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P2860
General anesthetic potencies of a series of propofol analogs correlate with potency for potentiation of gamma-aminobutyric acid (GABA) current at the GABA(A) receptor but not with lipid solubility.
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
General anesthetic potencies o ...... but not with lipid solubility.
@ast
General anesthetic potencies o ...... but not with lipid solubility.
@en
type
label
General anesthetic potencies o ...... but not with lipid solubility.
@ast
General anesthetic potencies o ...... but not with lipid solubility.
@en
prefLabel
General anesthetic potencies o ...... but not with lipid solubility.
@ast
General anesthetic potencies o ...... but not with lipid solubility.
@en
P2093
P1476
General anesthetic potencies o ...... but not with lipid solubility.
@en
P2093
P304
P407
P577
2001-04-01T00:00:00Z