Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.
about
The molecular pharmacology of volatile anestheticsCommon Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion ChannelStructure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic KetamineMultisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channelSignal Transduction Pathways in the Pentameric Ligand-Gated Ion ChannelsEthanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine ReceptorsMolecular mechanism for the dual alcohol modulation of Cys-loop receptorsThe Primitive Thylakoid-Less Cyanobacterium Gloeobacter Is a Common Rock-Dwelling OrganismUnderstanding of anesthesia - Why consciousness is essential for life and not based on genes.Propofol binding to the resting state of the gloeobacter violaceus ligand-gated ion channel (GLIC) induces structural changes in the inter- and intrasubunit transmembrane domain (TMD) cavitiesA membrane-embedded pathway delivers general anesthetics to two interacting binding sites in the Gloeobacter violaceus ion channel.Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain.Anesthetic binding in a pentameric ligand-gated ion channel: GLICRecognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis.GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sitesGeneral anesthetics predicted to block the GLIC pore with micromolar affinity.Atomistic models of general anesthetics for use in in silico biological studiesMolecular dynamics and brownian dynamics investigation of ion permeation and anesthetic halothane effects on a proton-gated ion channelAnesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.Macroscopic kinetics of pentameric ligand gated ion channels: comparisons between two prokaryotic channels and one eukaryotic channel.Structural basis for alcohol modulation of a pentameric ligand-gated ion channelFunctional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family.Isoflurane alters the structure and dynamics of GLIC.Allosteric regulation of pentameric ligand-gated ion channels: an emerging mechanistic perspectiveExpression and characterization of the bacterial mechanosensitive channel MscS in Xenopus laevis oocytesStructural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion ChannelDirect Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.Asymmetric ligand binding facilitates conformational transitions in pentameric ligand-gated ion channels.Structural sensitivity of a prokaryotic pentameric ligand-gated ion channel to its membrane environment.Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel.Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sitesShaker-related potassium channels in the central medial nucleus of the thalamus are important molecular targets for arousal suppression by volatile general anestheticsFunctional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channelsBarbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State.Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.Reversal of ion-charge selectivity renders the pentameric ligand-gated ion channel GLIC insensitive to anaestheticsGABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation.Assembly of nicotinic and other Cys-loop receptors.The discovery of new anesthetics by targeting GABA(A) receptors.
P2860
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P2860
Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.
@ast
Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.
@en
type
label
Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.
@ast
Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.
@en
prefLabel
Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.
@ast
Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.
@en
P2093
P2860
P1476
Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.
@en
P2093
James M Sonner
Pierre-Jean Corringer
P2860
P356
10.1213/ANE.0B013E3181C4BC69
P407
P577
2009-11-21T00:00:00Z