Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. - Wikidata - awgldk - TriplyDB

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

http://www.wikidata.org/entity/Q36172034

about

AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization.Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template.Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes Memory in the B-cell compartment: antibody affinity maturation Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes The evolution within us Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin AID/APOBEC deaminases and cancer Inferring processes underlying B-cell repertoire diversity Use of mutation spectra analysis software.Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data.A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data.An immunoglobulin mutator that targets G.C base pairs.Molecular analysis of immunoglobulin genes in multiple myeloma.Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation.The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response.Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men.Evolution and the molecular basis of somatic hypermutation of antigen receptor genes.Error-prone DNA repair activity during somatic hypermutation in shark B lymphocytes Genesis of the strand-biased signature in somatic hypermutation of rearranged immunoglobulin variable genes.Analysis of somatic mutation in five B cell subsets of human tonsil.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.B cell variable genes have evolved their codon usage to focus the targeted patterns of somatic mutation on the complementarity determining regions Directed evolution of human scFvs in DT40 cells.Differential V region mutation of two transfected Ig genes and their interaction in cultured B cell lines On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes.Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection.Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation.Both DNA strands of antibody genes are hypermutation targets.Antibodyomics: bioinformatics technologies for understanding B-cell immunity to HIV-1.BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci.In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells Random mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen.Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution

P2860

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P2860

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

http://www.wikidata.org/entity/Q36172034

description

1993 nî lūn-bûn

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Proceedings of the National Academy of Sciences of the United States of America

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Passenger transgenes reveal in ...... arity, and specific hot spots.

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P2093

A G Betz

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C Milstein

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C Rada

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M S Neuberger

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R Pannell

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P2860

The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops.

Patterns of somatic mutations in immunoglobulin variable genes

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.

Mutational hot spots in Ig V region genes of human follicular lymphomas

Clonal evolution of a follicular lymphoma: evidence for antigen selection.

Hierarchies of DNA repair in mammalian cells: biological consequences.

Mutation and selection during the secondary response to 2-phenyloxazolone.

Heterogeneity of DNA repair at the gene level.

Mutation drift and repertoire shift in the maturation of the immune response.

Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.

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2385-2388

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14739459

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8460148

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46091

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