The 3' IgH regulatory region: a complex structure in a search for a function.
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The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expressionLong-Range Regulation of V(D)J RecombinationThe HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombinationLong-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locusChromatin architecture near a potential 3' end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites.Elucidation of IgH intronic enhancer functions via germ-line deletionThe zebrafish IgH locus contains multiple transcriptional regulatory regions.The long winding road toward understanding the molecular mechanisms for B-cell suppression by 2,3,7,8-tetrachlorodibenzo-p-dioxinDirect interactions of OCA-B and TFII-I regulate immunoglobulin heavy-chain gene transcription by facilitating enhancer-promoter communication.Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.Chromatin dynamics and locus accessibility in the immune system.Dynamic changes in binding of immunoglobulin heavy chain 3' regulatory region to protein factors during class switching.Enhancer-promoter communication and transcriptional regulation of IghThe aryl hydrocarbon receptor regulates an essential transcriptional element in the immunoglobulin heavy chain gene.Complete cis Exclusion upon Duplication of the Eμ Enhancer at the Immunoglobulin Heavy Chain Locus.Hydrogen peroxide modulates immunoglobulin expression by targeting the 3'Igh regulatory region through an NFκB-dependent mechanismDevelopmental Switch in the Transcriptional Activity of a Long-Range Regulatory Element.Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulationThree-dimensional architecture of the IgH locus facilitates class switch recombination.Replacement of Igamma3 germ-line promoter by Igamma1 inhibits class-switch recombination to IgG3.Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3' regulatory region of the immunoglobulin heavy chain locus.Functional long-range interactions of the IgH 3' enhancers with the bcl-2 promoter region in t(14;18) lymphoma cellsS-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.Diverse chemicals including aryl hydrocarbon receptor ligands modulate transcriptional activity of the 3'immunoglobulin heavy chain regulatory region.The AhR and NF-κB/Rel Proteins Mediate the Inhibitory Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on the 3' Immunoglobulin Heavy Chain Regulatory Region.A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation.Allelic frequencies of 3' Ig heavy chain locus enhancer HS1,2-A associated with Ig levels in patients with schizophrenia.Epigenetic Regulation of Individual Modules of the immunoglobulin heavy chain locus 3' Regulatory Region.Seeking sense of antisense switch transcripts.Biased dA/dT somatic hypermutation as regulated by the heavy chain intronic iEmu enhancer and 3'Ealpha enhancers in human lymphoblastoid B cells.Sense transcription through the S region is essential for immunoglobulin class switch recombination.CD86 and beta2-adrenergic receptor signaling pathways, respectively, increase Oct-2 and OCA-B Expression and binding to the 3'-IgH enhancer in B cells.53BP1 Contributes to Igh Locus Chromatin Topology during Class Switch Recombination.Duplication of a germline promoter downstream of the IgH 3' regulatory region impairs class switch recombination.
P2860
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P2860
The 3' IgH regulatory region: a complex structure in a search for a function.
description
2000 nî lūn-bûn
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2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2000 թվականի հունվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
@zh-hant
2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
The 3' IgH regulatory region: a complex structure in a search for a function.
@ast
The 3' IgH regulatory region: a complex structure in a search for a function.
@en
type
label
The 3' IgH regulatory region: a complex structure in a search for a function.
@ast
The 3' IgH regulatory region: a complex structure in a search for a function.
@en
prefLabel
The 3' IgH regulatory region: a complex structure in a search for a function.
@ast
The 3' IgH regulatory region: a complex structure in a search for a function.
@en
P2093
P1476
The 3' IgH regulatory region: a complex structure in a search for a function.
@en
P2093
P304
P356
10.1016/S0065-2776(00)75008-5
P577
2000-01-01T00:00:00Z