A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation.
about
Epigenetic control of immunityMemories of lost enhancersThe requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.Epigenetic regulation of antigen receptor gene rearrangementUsing BAC transgenesis in zebrafish to identify regulatory sequences of the amyloid precursor protein gene in humans.Insertion of an imprinted insulator into the IgH locus reveals developmentally regulated, transcription-dependent control of V(D)J recombination.The eleven-nineteen lysine-rich leukemia gene (ELL2) influences the histone H3 protein modifications accompanying the shift to secretory immunoglobulin heavy chain mRNA productionEnhancer-promoter communication and transcriptional regulation of IghComplete cis Exclusion upon Duplication of the Eμ Enhancer at the Immunoglobulin Heavy Chain Locus.A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformationDevelopmental Switch in the Transcriptional Activity of a Long-Range Regulatory Element.Noncoding transcription within the Igh distal V(H) region at PAIR elements affects the 3D structure of the Igh locus in pro-B cellsTwo forms of loops generate the chromatin conformation of the immunoglobulin heavy-chain gene locus.Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctionsRegulation of antigen receptor gene assembly by genetic-epigenetic crosstalk.Epigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'.Histone methylation and V(D)J recombination.Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire.Sequential Enhancer Sequestration Dysregulates Recombination Center Formation at the IgH Locus.Epigenetic regulation of antigen receptor gene rearrangement.
P2860
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P2860
A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 04 May 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A 220-nucleotide deletion of t ...... heavy chain locus activation.
@en
A 220-nucleotide deletion of t ...... heavy chain locus activation.
@nl
type
label
A 220-nucleotide deletion of t ...... heavy chain locus activation.
@en
A 220-nucleotide deletion of t ...... heavy chain locus activation.
@nl
prefLabel
A 220-nucleotide deletion of t ...... heavy chain locus activation.
@en
A 220-nucleotide deletion of t ...... heavy chain locus activation.
@nl
P2093
P2860
P356
P1476
A 220-nucleotide deletion of t ...... heavy chain locus activation.
@en
P2093
Anant Jani
Frederick W Alt
Irina Ivanova
Peter H Goff
Ramesh Subrahmanyam
Ranjan Sen
Thomas Perlot
Tirtha Chakraborty
P2860
P304
P356
10.1084/JEM.20081621
P407
P577
2009-05-04T00:00:00Z