Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation. - Wikidata - awgldk - TriplyDB

Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation.

Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation.

http://www.wikidata.org/entity/Q33957925

about

The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms Extracellular matrix as target for antitumor therapy A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission Extracellular signal-regulated kinase 1/2 activity is not required in mammalian cells during late G2 for timely entry into or exit from mitosis Mitogen-activated protein kinase kinase 1-dependent Golgi unlinking occurs in G2 phase and promotes the G2/M cell cycle transition.Growth arrest signaling of the Raf/MEK/ERK pathway in cancer.ERK2 enters the nucleus by a carrier-independent mechanism Quantitative analysis of ERK2 interactions with substrate proteins: roles for kinase docking domains and activity in determining binding affinity.Signal transduction by MAP kinases: regulation by phosphorylation-dependent switches.Changes in protein conformational mobility upon activation of extracellular regulated protein kinase-2 as detected by hydrogen exchange.Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells Ras-MAP kinase signaling pathways and control of cell proliferation: relevance to cancer therapy.Abrogated thioredoxin system causes increased sensitivity to TNF-α-induced apoptosis via enrichment of p-ERK 1/2 in the nucleus.Functional and molecular interactions between ERK and CHK2 in diffuse large B-cell lymphoma All tangled up: how cells direct, manage and exploit topoisomerase function.Topoisomerase IIα in chromosome instability and personalized cancer therapy.Characterization of ATP-independent ERK inhibitors identified through in silico analysis of the active ERK2 structure Inhibiting MAP kinase activity prevents calcium transients and mitosis entry in early sea urchin embryos Epstein-Barr virus BGLF4 kinase induces premature chromosome condensation through activation of condensin and topoisomerase II.Structural Basis for the Non-catalytic Functions of Protein Kinases.Targeting prostate cancer based on signal transduction and cell cycle pathways.Working without kinase activity: phosphotransfer-independent functions of extracellular signal-regulated kinases.The secret life of kinases: functions beyond catalysis Control of gp130 expression by the mitogen-activated protein kinase ERK2.Ataxia telangiectasia mutated-dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor.Modulation of anthracycline-induced cytotoxicity by targeting the prenylated proteome in myeloid leukemia cells.Neoamphimedine circumvents metnase-enhanced DNA topoisomerase IIα activity through ATP-competitive inhibition Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling.Phosphorylation regulates nucleophosmin targeting to the centrosome during mitosis as detected by cross-reactive phosphorylation-specific MKK1/MKK2 antibodies.Regulation of Catalytic and Non-catalytic Functions of the Drosophila Ste20 Kinase Slik by Activation Segment Phosphorylation Tyrosine-phosphorylated extracellular signal--regulated kinase associates with the Golgi complex during G2/M phase of the cell cycle: evidence for regulation of Golgi structure Involvement of the MAP kinase ERK2 in MUC1 mucin signaling.ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma-lamin A complexes.MAPK mediates RAS-induced chromosome instability.Overexpression of the atypical protein kinase C zeta reduces topoisomerase II catalytic activity, cleavable complexes formation, and drug-induced cytotoxicity in monocytic U937 leukemia cells.The interaction of Bex and OMP reveals a dimer of OMP with a short half-life.DNA topoisomerase II is required for the G0-to-S phase transition in Drosophila Schneider cells, but not in yeast.Expression of Topoisomerase II-α protein in salivary gland tumors.A cellular threshold for active ERK1/2 levels determines Raf/MEK/ERK-mediated growth arrest versus death responses.

P2860

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P2860

Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation.

http://www.wikidata.org/entity/Q33957925

description

1999 nî lūn-bûn

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1999 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի մայիսին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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name

Extracellular signal-regulated ...... ndependent of phosphorylation.

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Extracellular signal-regulated ...... ndependent of phosphorylation.

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type

label

Extracellular signal-regulated ...... ndependent of phosphorylation.

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Extracellular signal-regulated ...... ndependent of phosphorylation.

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prefLabel

Extracellular signal-regulated ...... ndependent of phosphorylation.

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Extracellular signal-regulated ...... ndependent of phosphorylation.

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Molecular and Cellular Biology

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Extracellular signal-regulated ...... ndependent of phosphorylation.

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P2093

A M Whalen

http://www.w3.org/2001/XMLSchema#string

J Wilsbacher

http://www.w3.org/2001/XMLSchema#string

M Garcia

http://www.w3.org/2001/XMLSchema#string

N G Ahn

http://www.w3.org/2001/XMLSchema#string

N Osheroff

http://www.w3.org/2001/XMLSchema#string

N S Tolwinski

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P S Shapiro

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S J Froelich-Ammon

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P2860

Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities

Mitotic inactivation of a human SWI/SNF chromatin remodeling complex

Active MAP kinase in mitosis: localization at kinetochores and association with the motor protein CENP-E

DNA topoisomerase II and casein kinase II associate in a molecular complex that is catalytically active.

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

Role of nonhistone proteins in the chromosomal events of mitosis

Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

Transformation of mammalian cells by constitutively active MAP kinase kinase

DNA topoisomerases

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3551-3560

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10.1128/MCB.19.5.3551

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5

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19

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1999-05-01T00:00:00Z

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13091351

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10207078

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phosphorylation

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84147

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