about
Kaposi's sarcoma-associated herpesvirus induction of AP-1 and interleukin 6 during primary infection mediated by multiple mitogen-activated protein kinase pathways.The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.Identification of a kinase profile that predicts chromosome damage induced by small molecule kinase inhibitorsRaf kinase inhibitory protein regulates aurora B kinase and the spindle checkpointMyocardin related transcription factors are required for coordinated cell cycle progression.Extracellular signal-regulated kinase 1/2 activity is not required in mammalian cells during late G2 for timely entry into or exit from mitosisMultipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos.Activation of extracellular signal-regulated kinase (ERK) in G2 phase delays mitotic entry through p21CIP1.E2F activators signal and maintain centrosome amplification in breast cancer cells.Expanding applications of chemical genetics in signal transduction.The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2EGFR gene variants are associated with specific somatic aberrations in glioma.The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification.A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogasterp38α MAPK is a MTOC-associated protein regulating spindle assembly, spindle length and accurate chromosome segregation during mouse oocyte meiotic maturation.Cdk4 and nek2 signal binucleation and centrosome amplification in a her2+ breast cancer model.Constitutive ERK1/2 activation contributes to production of double minute chromosomes in tumour cellsRas-MAP kinase signaling pathways and control of cell proliferation: relevance to cancer therapy.Role of NEK2A in human cancer and its therapeutic potentials.Human endogenous retroviral K element encodes fusogenic activity in melanoma cells.The G2 p38-mediated stress-activated checkpoint pathway becomes attenuated in transformed cellsEndogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogeneMechanisms of aneuploidy induction by RAS and RAF oncogenesCancer cell micronucleus: an update on clinical and diagnostic applications.The cancer biology of whole-chromosome instability.Signal transduction in cancerSynergistic effect of EMS1-shRNA and sorafenib on proliferation, migration, invasion and endocytosis of SMMC-7721.Chromosomal Instability in Gastric Cancer Biology.Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells.Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability.Cdc2-mediated inhibition of epidermal growth factor activation of the extracellular signal-regulated kinase pathway during mitosis.Activation of Ras-Ral pathway attenuates p53-independent DNA damage G2 checkpoint.Enhanced expression of MYCN leads to centrosome hyperamplification after DNA damage in neuroblastoma cells.Oncogenic KRAS triggers MAPK-dependent errors in mitosis and MYC-dependent sensitivity to anti-mitotic agents.Kaposi's sarcoma-associated herpesvirus induction of chromosome instability in primary human endothelial cells.Fission yeast Ras1 effector Scd1 interacts with the spindle and affects its proper formation.Inactivation of E2F3 results in centrosome amplification.MAP kinase meets mitosis: a role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation.Hyperploidy induced by drugs that inhibit formation of microtubule promotes chromosome instability.Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.
P2860
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P2860
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
MAPK mediates RAS-induced chromosome instability.
@en
MAPK mediates RAS-induced chromosome instability.
@nl
type
label
MAPK mediates RAS-induced chromosome instability.
@en
MAPK mediates RAS-induced chromosome instability.
@nl
prefLabel
MAPK mediates RAS-induced chromosome instability.
@en
MAPK mediates RAS-induced chromosome instability.
@nl
P2093
P2860
P356
P1476
MAPK mediates RAS-induced chromosome instability.
@en
P2093
Fukasawa K
Saavedra HI
Stambrook PJ
P2860
P304
38083-38090
P356
10.1074/JBC.274.53.38083
P407
P577
1999-12-01T00:00:00Z