SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. - Wikidata - awgldk - TriplyDB

SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation.

SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation.

http://www.wikidata.org/entity/Q33958723

about

Principles of interleukin (IL)-6-type cytokine signalling and its regulation Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3 Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.E3 ubiquitin ligases and their control of T cell autoreactivity The biology and mechanism of action of suppressor of cytokine signaling 3 The role of suppressors of cytokine signalling in human neoplasms SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2 Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance Negative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3)Regulation of expression of the rat SOCS-3 gene in hepatocytes by growth hormone, interleukin-6 and glucocorticoids mRNA analysis and promoter characterization Tyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation.SOCS1 and SOCS3 in the control of CNS immunity A new polycythaemia vera-associated SOCS3 SH2 mutant (SOCS3F136L) cannot regulate erythropoietin responses Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor A cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5b.Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation.Suppressors of cytokine signaling 1 and 3 are upregulated in brain resident cells in response to virus-induced inflammation of the central nervous system via at least two distinctive pathways.SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis.Intersection of mTOR and STAT signaling in immunity Regulation of IFN-gamma signaling is essential for the cytotoxic activity of CD8(+) T cells Are SOCS suppressors, regulators, and degraders?Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130 Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2.Specific Jak3 Downregulation in Lymphocytes Impairs γc Cytokine Signal Transduction and Alleviates Antigen-driven Inflammation In Vivo The role of endotoxin, TNF-alpha, and IL-6 in inducing the state of growth hormone insensitivity.Suppressor of cytokine signaling 3 (SOCS3) in Th2 cells evokes Th2 cytokines, IgE, and eosinophilia.Sepsis-induced SOCS-3 expression is immunologically restricted to phagocytes.Putative mechanism of hemorrhage-induced leukocyte hyporesponsiveness: induction of suppressor of cytokine signaling-3.Differential regulation of SOCS genes in normal and transformed erythroid cells.PDGF-driven proliferation, migration, and IL8 chemokine secretion in human corneal fibroblasts involve JAK2-STAT3 signaling pathway Biology of porcine T lymphocytes.

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P2860

SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation.

http://www.wikidata.org/entity/Q33958723

description

1999 nî lūn-bûn

@nan

1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

1999年の論文

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1999年論文

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1999年論文

@zh-hant

1999年論文

@zh-hk

1999年論文

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1999年論文

@zh-tw

1999年论文

@wuu

name

SOCS-3 is tyrosine phosphoryla ...... and lymphocyte proliferation.

@ast

SOCS-3 is tyrosine phosphoryla ...... and lymphocyte proliferation.

@en

type

label

SOCS-3 is tyrosine phosphoryla ...... and lymphocyte proliferation.

@ast

SOCS-3 is tyrosine phosphoryla ...... and lymphocyte proliferation.

@en

prefLabel

SOCS-3 is tyrosine phosphoryla ...... and lymphocyte proliferation.

@ast

SOCS-3 is tyrosine phosphoryla ...... and lymphocyte proliferation.

@en

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Molecular and Cellular Biology

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SOCS-3 is tyrosine phosphoryla ...... and lymphocyte proliferation.

@en

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A Mui

http://www.w3.org/2001/XMLSchema#string

A Yoshimura

http://www.w3.org/2001/XMLSchema#string

D Sanden

http://www.w3.org/2001/XMLSchema#string

J A Johnston

http://www.w3.org/2001/XMLSchema#string

N A Cacalano

http://www.w3.org/2001/XMLSchema#string

S J Cohney

http://www.w3.org/2001/XMLSchema#string

T S Migone

http://www.w3.org/2001/XMLSchema#string

P2860

A family of cytokine-inducible inhibitors of signalling

A new protein containing an SH2 domain that inhibits JAK kinases

Twenty proteins containing a C-terminal SOCS box form five structural classes

Cloning and characterization of novel CIS family genes

Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors

Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain

Specific inhibition of Stat3 signal transduction by PIAS3

Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein

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4980-4988

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10.1128/MCB.19.7.4980

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7

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19

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12924640

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10373548

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P921

phosphorylation

P932

84319

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