Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1 - Wikidata - awgldk - TriplyDB

Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1

Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1

http://www.wikidata.org/entity/Q33963772

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Pseudomonas Exotoxin A: optimized by evolution for effective killing The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy Newly Discovered and Characterized Antivirulence Compounds Inhibit Bacterial Mono-ADP-Ribosyltransferase Toxins Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor BAK and NOXA are critical determinants of mitochondrial apoptosis induced by bortezomib in mesothelioma Paclitaxel synergizes with exposure time adjusted CD22-targeting immunotoxins against B-cell malignancies.Paclitaxel-induced apoptosis is BAK-dependent, but BAX and BIM-independent in breast tumor.Methylation-associated partial down-regulation of mesothelin causes resistance to anti-mesothelin immunotoxins in a pancreatic cancer cell line.Killing of resistant cancer cells with low Bak by a combination of an antimesothelin immunotoxin and a TRAIL Receptor 2 agonist antibody.A guide to taming a toxin--recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer.Characterization of Cholix toxin-induced apoptosis in HeLa cells.Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox The cytotoxicity of anti-CD22 immunotoxin is enhanced by bryostatin 1 in B-cell lymphomas through CD22 upregulation and PKC-βII depletion.Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy.Immunoconjugates in the management of hairy cell leukemia.The insulin receptor negatively regulates the action of Pseudomonas toxin-based immunotoxins and native Pseudomonas toxin.A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene.Protein Kinase Inhibitor H89 Enhances the Activity of Pseudomonas Exotoxin A-Based Immunotoxins.Actinomycin D enhances killing of cancer cells by immunotoxin RG7787 through activation of the extrinsic pathway of apoptosis.Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8.Antitumor effects of immunotoxins are enhanced by lowering HCK or treatment with SRC kinase inhibitors.Mesothelin-targeted immunotoxin RG7787 has synergistic anti-tumor activity when combined with taxanes Enhancing immunotoxin cell-killing activity via combination therapy with ABT-737.Pseudomonas aeruginosa: new insights into pathogenesis and host defenses.Macrophage cell death in microbial infections.Targeting a Cancer-Specific Epitope of the Epidermal Growth Factor Receptor in Triple-Negative Breast Cancer.Structural complementation of the catalytic domain of pseudomonas exotoxin A Antileukemia Efficacy and Mechanisms of Action of SL-101, a Novel Anti-CD123 Antibody Conjugate, in Acute Myeloid Leukemia.HER2-specific recombinant immunotoxin 4D5scFv-PE40 passes through retrograde trafficking route and forces cells to enter apoptosis Apoptosis induced by Pseudomonas aeruginosa: a lonely killer?Bcl-2 family proteins and cytoskeleton changes involved in DM-1 cytotoxic effect on melanoma cells.

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P2860

Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1

http://www.wikidata.org/entity/Q33963772

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Pseudomonas exotoxin A-mediate ...... ed by the degradation of Mcl-1

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Pseudomonas exotoxin A-mediate ...... ed by the degradation of Mcl-1

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Pseudomonas exotoxin A-mediate ...... ed by the degradation of Mcl-1

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Pseudomonas exotoxin A-mediate ...... ed by the degradation of Mcl-1

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Pseudomonas exotoxin A-mediate ...... ed by the degradation of Mcl-1

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Pseudomonas exotoxin A-mediate ...... ed by the degradation of Mcl-1

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Molecular and Cellular Biology

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Pseudomonas exotoxin A-mediate ...... ed by the degradation of Mcl-1

@en

P2093

David J FitzGerald

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Ira Pastan

http://www.w3.org/2001/XMLSchema#string

Richard J Youle

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Xing Du

http://www.w3.org/2001/XMLSchema#string

P2860

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

The Bcl-2 apoptotic switch in cancer development and therapy

Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway

Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

Tumor cell metabolism: cancer's Achilles' heel

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3444-3452

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scholarly article

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10.1128/MCB.00813-09

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14

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30

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2010-05-10T00:00:00Z

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44587658

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20457813

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2897547

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