ARF-induced downregulation of Mip130/LIN-9 protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf.
about
Cellular senescence and tumor suppressor gene p16LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression.Loss of LIN9, a member of the DREAM complex, cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growth.Downregulation of B-myb promotes senescence via the ROS-mediated p53/p21 pathway, in vascular endothelial cells.
P2860
ARF-induced downregulation of Mip130/LIN-9 protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
ARF-induced downregulation of ...... ession of p16Ink4a and p19Arf.
@ast
ARF-induced downregulation of ...... ession of p16Ink4a and p19Arf.
@en
type
label
ARF-induced downregulation of ...... ession of p16Ink4a and p19Arf.
@ast
ARF-induced downregulation of ...... ession of p16Ink4a and p19Arf.
@en
prefLabel
ARF-induced downregulation of ...... ession of p16Ink4a and p19Arf.
@ast
ARF-induced downregulation of ...... ession of p16Ink4a and p19Arf.
@en
P2093
P2860
P356
P1433
P1476
ARF-induced downregulation of ...... ession of p16Ink4a and p19Arf.
@en
P2093
M A Pilkinton
O R Colamonici
P Raychaudhuri
R Sandoval
P2860
P2888
P304
P356
10.1038/ONC.2009.485
P407
P577
2010-01-18T00:00:00Z
P5875
P6179
1020333257