A common enzyme connects notch signaling and Alzheimer's disease.
about
Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERMThe presenilinsThe immunological synapse: the gateway to the HIV reservoirPhysiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1Structural basis for autoinhibition of NotchCompounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeuticsA functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylationMind bomb 1 is required for pancreatic β-cell formationPresenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expressionCharacterization of N-terminal processing of group VIA phospholipase A2 and of potential cleavage sites of amyloid precursor protein constructs by automated identification of signature peptides in LC/MS/MS analyses of proteolytic digests.Genomewide expression analysis in zebrafish mind bomb alleles with pancreas defects of different severity identifies putative Notch responsive genesA miniaturized 1536-well format gamma-secretase assayModulation of gamma-secretase specificity using small molecule allosteric inhibitors.Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.Allosteric regulation of protease activity by small molecules.Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel.Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.Notch1IC partially replaces EBNA2 function in B cells immortalized by Epstein-Barr virus.APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryosPresenilin-dependent gamma-secretase activity modulates thymocyte development.The notch intracellular domain can function as a coactivator for LEF-1Notch receptor cleavage depends on but is not directly executed by presenilins.The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog?A fly's eye view of EGF receptor signallingL655,240, acting as a competitive BACE1 inhibitor, efficiently decreases β-amyloid peptide production in HEK293-APPswe cells.The proliferation of Drosophila in cancer research: a system for the functional characterization of tumor suppressors and oncogenes.OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin.Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity.The Notch signalling system: recent insights into the complexity of a conserved pathwayNotch signaling in the immune system.Regulation of dendritic-cell differentiation by bone marrow stroma via different Notch ligands.Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACESuppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans.Gamma secretase inhibitor enhances sensitivity to doxorubicin in MDA-MB-231 cells.Drosophila, the golden bug, emerges as a tool for human genetics.Notch1 Autoactivation via Transcriptional Regulation of Furin, Which Sustains Notch1 Signaling by Processing Notch1-Activating Proteases ADAM10 and Membrane Type 1 Matrix MetalloproteinaseDrosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component.Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex.Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease
P2860
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P2860
A common enzyme connects notch signaling and Alzheimer's disease.
description
2000 nî lūn-bûn
@nan
2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
name
A common enzyme connects notch signaling and Alzheimer's disease.
@ast
A common enzyme connects notch signaling and Alzheimer's disease.
@en
A common enzyme connects notch signaling and Alzheimer's disease.
@nl
type
label
A common enzyme connects notch signaling and Alzheimer's disease.
@ast
A common enzyme connects notch signaling and Alzheimer's disease.
@en
A common enzyme connects notch signaling and Alzheimer's disease.
@nl
prefLabel
A common enzyme connects notch signaling and Alzheimer's disease.
@ast
A common enzyme connects notch signaling and Alzheimer's disease.
@en
A common enzyme connects notch signaling and Alzheimer's disease.
@nl
P356
P1433
P1476
A common enzyme connects notch signaling and Alzheimer's disease.
@en
P304
P356
10.1101/GAD.836900
P577
2000-11-01T00:00:00Z