Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice
about
Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation.Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutationsTrehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.Progranulin and Its Related MicroRNAs after Status Epilepticus: Possible Mechanisms of Neuroprotection.Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS.Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.Lack of estrogen receptor α in astrocytes of progranulin-deficient mice.Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiencyProgranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer's disease model mice.The lysosomal protein cathepsin L is a progranulin protease.Progranulin, lysosomal regulation and neurodegenerative disease.Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementia.Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.NCLs and ER: A stressful relationship.Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations.Commentary: Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient miceThe Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death.Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis.Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency.Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients.The lysosomal function of progranulin, a guardian against neurodegenerationProgranulin Deficient Mice Develop Nephrogenic Diabetes InsipidusEarly lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice
P2860
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P2860
Possible involvement of lysosomal dysfunction in pathological changes of the brain in aged progranulin-deficient mice
description
2014 nî lūn-bûn
@nan
2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Possible involvement of lysoso ...... ged progranulin-deficient mice
@ast
Possible involvement of lysoso ...... ged progranulin-deficient mice
@en
Possible involvement of lysoso ...... ged progranulin-deficient mice
@nl
type
label
Possible involvement of lysoso ...... ged progranulin-deficient mice
@ast
Possible involvement of lysoso ...... ged progranulin-deficient mice
@en
Possible involvement of lysoso ...... ged progranulin-deficient mice
@nl
prefLabel
Possible involvement of lysoso ...... ged progranulin-deficient mice
@ast
Possible involvement of lysoso ...... ged progranulin-deficient mice
@en
Possible involvement of lysoso ...... ged progranulin-deficient mice
@nl
P2093
P2860
P1476
Possible involvement of lysoso ...... ged progranulin-deficient mice
@en
P2093
James K Chambers
Keitaro Yamanouchi
Masugi Nishihara
Takashi Matsuwaki
Yoshinori Tanaka
P2860
P356
10.1186/PREACCEPT-4589926441299369
P577
2014-07-15T00:00:00Z