Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4).
about
Aggrecanases and cartilage matrix degradationHigh resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate.Cleavage within Reelin repeat 3 regulates the duration and range of the signaling activity of Reelin protein.Mechanical load inhibits IL-1 induced matrix degradation in articular cartilageCoculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activityADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein.Matrix metalloproteinase inhibitors for cancer therapy:the current situation and future prospects.Mechanical Loading of Articular Cartilage Reduces IL-1-Induced Enzyme ExpressionThe effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants.Nitric oxide enhances aggrecan degradation by aggrecanase in response to TNF-alpha but not IL-1beta treatment at a post-transcriptional level in bovine cartilage explants.Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repairNeuroinflammation in the aging down syndrome brain; lessons from Alzheimer's disease.An enzyme-sensitive PEG hydrogel based on aggrecan catabolism for cartilage tissue engineeringAge-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains.Critical amino acids in the active site of meprin metalloproteinases for substrate and peptide bond specificity.Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis.Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis.Elucidating the function of non catalytic domains of collagenases and aggrecanases.Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage.Expression of versican and ADAMTS1, 4, and 5 during bone development in the rat mandible and hind limb.Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters.Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB.Variations in aggrecan structure modulate its susceptibility to aggrecanases.The structure and degradation of aggrecan in human intervertebral discDomain shuffling and the evolution of vertebrates.A quantitative assay for aggrecanase activity.Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice.IL-21 Enhances the Degradation of Cartilage Through the JAK-STAT Signaling Pathway During Osteonecrosis of Femoral Head Cartilage.Keratan Sulphate, a complex Glycosaminoglycan with Unique Functional Capability.Biomimetic nucleus pulposus scaffold created from bovine caudal intervertebral disc tissue utilizing an optimal decellularization procedure.Expression of ADAMTS-1, -4, -5 and TIMP-3 in normal and multiple sclerosis CNS white matter.Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus.Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage.MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover.Aggrecanase analysis of synovial fluid of temporomandibular joint disorders.
P2860
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P2860
Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4).
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Characterization of human aggr ...... with aggrecanase 1 (ADAM-TS4).
@ast
Characterization of human aggr ...... with aggrecanase 1 (ADAM-TS4).
@en
Characterization of human aggrecanase 2
@nl
type
label
Characterization of human aggr ...... with aggrecanase 1 (ADAM-TS4).
@ast
Characterization of human aggr ...... with aggrecanase 1 (ADAM-TS4).
@en
Characterization of human aggrecanase 2
@nl
prefLabel
Characterization of human aggr ...... with aggrecanase 1 (ADAM-TS4).
@ast
Characterization of human aggr ...... with aggrecanase 1 (ADAM-TS4).
@en
Characterization of human aggrecanase 2
@nl
P2093
P1433
P1476
Characterization of human aggr ...... with aggrecanase 1 (ADAM-TS4).
@en
P2093
Elizabeth Arner
Micky D Tortorella
Robert C Newton
Rui-Qin Liu
Timothy Burn
P304
P356
10.1016/S0945-053X(02)00069-0
P577
2002-10-01T00:00:00Z