Batrachotoxin-resistant Na+ channels derived from point mutations in transmembrane segment D4-S6
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Residue-specific effects on slow inactivation at V787 in D2-S6 of Na(v)1.4 sodium channels.A point mutation in domain 4-segment 6 of the skeletal muscle sodium channel produces an atypical inactivation state.Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channelsResidues in Na(+) channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities.Neurotoxins and their binding areas on voltage-gated sodium channels.Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels.Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel.Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison Frogs.Animal toxins can alter the function of Nav1.8 and Nav1.9.Sodium channel inactivation: molecular determinants and modulation.Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels.Modular Synthesis of the Pentacyclic Core of Batrachotoxin and Select Batrachotoxin Analogue DesignsThe external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na(+) channelAccessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents.Veratridine block of rat skeletal muscle Nav1.4 sodium channels in the inner vestibule.A "minimal" sodium channel construct consisting of ligated S5-P-S6 segments forms a toxin-activatable ionophore.Activation of Drosophila sodium channels promotes modification by deltamethrin. Reductions in affinity caused by knock-down resistance mutations.Inhibition of Sodium Ion Channel Function with Truncated Forms of Batrachotoxin.State-dependent inter-repeat contacts of exceptionally conserved asparagines in the inner helices of sodium and calcium channels.Binding of the anticonvulsant drug lamotrigine and the neurotoxin batrachotoxin to voltage-gated sodium channels induces conformational changes associated with block and steady-state activation.The selectivity filter of the voltage-gated sodium channel is involved in channel activation.Distinct sites regulating grayanotoxin binding and unbinding to D4S6 of Na(v)1.4 sodium channel as revealed by improved estimation of toxin sensitivity.Dietary alkaloid sequestration in a poison frog: an experimental test of alkaloid uptake in Melanophryniscus stelzneri (Bufonidae).Allosteric interactions among pyrethroid, brevetoxin, and scorpion toxin receptors on insect sodium channels raise an alternative approach for insect control.Toxins That Affect Voltage-Gated Sodium Channels.Single rat muscle Na+ channel mutation confers batrachotoxin autoresistance found in poison-dart frog Phyllobates terribilis.Asymmetric synthesis of batrachotoxin: Enantiomeric toxins show functional divergence against NaV.
P2860
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P2860
Batrachotoxin-resistant Na+ channels derived from point mutations in transmembrane segment D4-S6
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Batrachotoxin-resistant Na+ ch ...... in transmembrane segment D4-S6
@ast
Batrachotoxin-resistant Na+ ch ...... in transmembrane segment D4-S6
@en
Batrachotoxin-resistant Na+ ch ...... in transmembrane segment D4-S6
@nl
type
label
Batrachotoxin-resistant Na+ ch ...... in transmembrane segment D4-S6
@ast
Batrachotoxin-resistant Na+ ch ...... in transmembrane segment D4-S6
@en
Batrachotoxin-resistant Na+ ch ...... in transmembrane segment D4-S6
@nl
prefLabel
Batrachotoxin-resistant Na+ ch ...... in transmembrane segment D4-S6
@ast
Batrachotoxin-resistant Na+ ch ...... in transmembrane segment D4-S6
@en
Batrachotoxin-resistant Na+ ch ...... in transmembrane segment D4-S6
@nl
P2860
P1433
P1476
Batrachotoxin-resistant Na+ ch ...... in transmembrane segment D4-S6
@en
P2093
P2860
P304
P356
10.1016/S0006-3495(99)77465-5
P407
P577
1999-06-01T00:00:00Z