Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin
about
The hitchhiker's guide to the voltage-gated sodium channel galaxyGinseng ginsenoside pharmacology in the nervous system: involvement in the regulation of ion channels and receptorsState-dependent action of grayanotoxin I on Na(+) channels in frog ventricular myocytesResidue-specific effects on slow inactivation at V787 in D2-S6 of Na(v)1.4 sodium channels.Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channelConstraint shapes convergence in tetrodotoxin-resistant sodium channels of snakesBatrachotoxin-resistant Na+ channels derived from point mutations in transmembrane segment D4-S6A point mutation in domain 4-segment 6 of the skeletal muscle sodium channel produces an atypical inactivation state.Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channelsResidues in Na(+) channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities.Tryptophan scanning of D1S6 and D4S6 C-termini in voltage-gated sodium channelsNeurotoxins and their binding areas on voltage-gated sodium channels.Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anestheticsThe molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels.Analysis of the action of lidocaine on insect sodium channels.The poison Dart frog's batrachotoxin modulates Nav1.8.Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels.Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel.Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison Frogs.Sodium channel inactivation: molecular determinants and modulation.Modular Synthesis of the Pentacyclic Core of Batrachotoxin and Select Batrachotoxin Analogue DesignsPersistent human cardiac Na+ currents in stably transfected mammalian cells: Robust expression and distinct open-channel selectivity among Class 1 antiarrhythmics.Animal toxins influence voltage-gated sodium channel function.Veratridine block of rat skeletal muscle Nav1.4 sodium channels in the inner vestibule.Comparison of aconitine-modified human heart (hH1) and rat skeletal (mu1) muscle Na+ channels: an important role for external Na+ ions.Activation of Drosophila sodium channels promotes modification by deltamethrin. Reductions in affinity caused by knock-down resistance mutations.Inhibition of Sodium Ion Channel Function with Truncated Forms of Batrachotoxin.State-dependent inter-repeat contacts of exceptionally conserved asparagines in the inner helices of sodium and calcium channels.Binding of the anticonvulsant drug lamotrigine and the neurotoxin batrachotoxin to voltage-gated sodium channels induces conformational changes associated with block and steady-state activation.Alkaloids from Veratrum taliense Exert Cardiovascular Toxic Effects via Cardiac Sodium Channel Subtype 1.5.Distinct sites regulating grayanotoxin binding and unbinding to D4S6 of Na(v)1.4 sodium channel as revealed by improved estimation of toxin sensitivity.Mutations in the transmembrane helix S6 of domain IV confer cockroach sodium channel resistance to sodium channel blocker insecticides and local anesthetics.Allosteric interactions among pyrethroid, brevetoxin, and scorpion toxin receptors on insect sodium channels raise an alternative approach for insect control.delta-Atracotoxins from australian funnel-web spiders compete with scorpion alpha-toxin binding but differentially modulate alkaloid toxin activation of voltage-gated sodium channels.A slowly inactivating sodium current (INa2) in the plateau range in canine cardiac Purkinje single cells.A single amino acid change makes a rat neuronal sodium channel highly sensitive to pyrethroid insecticides.Toxins That Affect Voltage-Gated Sodium Channels.Single rat muscle Na+ channel mutation confers batrachotoxin autoresistance found in poison-dart frog Phyllobates terribilis.Asymmetric synthesis of batrachotoxin: Enantiomeric toxins show functional divergence against NaV.
P2860
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P2860
Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin
description
1998 nî lūn-bûn
@nan
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Point mutations in segment I-S ...... els resistant to batrachotoxin
@ast
Point mutations in segment I-S ...... els resistant to batrachotoxin
@en
Point mutations in segment I-S ...... els resistant to batrachotoxin
@nl
type
label
Point mutations in segment I-S ...... els resistant to batrachotoxin
@ast
Point mutations in segment I-S ...... els resistant to batrachotoxin
@en
Point mutations in segment I-S ...... els resistant to batrachotoxin
@nl
prefLabel
Point mutations in segment I-S ...... els resistant to batrachotoxin
@ast
Point mutations in segment I-S ...... els resistant to batrachotoxin
@en
Point mutations in segment I-S ...... els resistant to batrachotoxin
@nl
P2860
P356
P1476
Point mutations in segment I-S ...... els resistant to batrachotoxin
@en
P2093
P2860
P304
P356
10.1073/PNAS.95.5.2653
P407
P577
1998-03-03T00:00:00Z