Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channels
about
Residue-specific effects on slow inactivation at V787 in D2-S6 of Na(v)1.4 sodium channels.A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channelOuter pore topology of the ECaC-TRPV5 channel by cysteine scan mutagenesis.Identification of new batrachotoxin-sensing residues in segment IIIS6 of the sodium channel.Subunit dependence of Na channel slow inactivation and open channel block in cerebellar neuronsGating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor.Slow inactivation does not block the aqueous accessibility to the outer pore of voltage-gated Na channels.The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na(+) channelThe outer vestibule of the Na+ channel-toxin receptor and modulator of permeation as well as gating.Relative resistance to slow inactivation of human cardiac Na+ channel hNav1.5 is reversed by lysine or glutamine substitution at V930 in D2-S6.Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents.MTSET modification of D4S6 cysteines stabilize the fast inactivated state of Nav1.5 sodium channels.Inhibition of Sodium Ion Channel Function with Truncated Forms of Batrachotoxin.Binding of the anticonvulsant drug lamotrigine and the neurotoxin batrachotoxin to voltage-gated sodium channels induces conformational changes associated with block and steady-state activation.The selectivity filter of the voltage-gated sodium channel is involved in channel activation.Mechanisms of Drug Binding to Voltage-Gated Sodium Channels.Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na+ channels: mechanistic insights from recent crystal structures.Characterization of specific allosteric effects of the Na+ channel β1 subunit on the Nav1.4 isoform.Interaction between fast and ultra-slow inactivation in the voltage-gated sodium channel. Does the inactivation gate stabilize the channel structure?
P2860
Q28359616-1634EF7C-0DA7-49B4-8831-5AC48B8BFB63Q28579256-6D2D5D17-8749-48A1-A8B1-3945A8C976BDQ34278221-8D94BBC7-233B-4709-A070-21D8A63B75C3Q34787096-7C25FBD8-EC24-43A7-8466-3FD9B278DF28Q35774461-E6DF3368-B5A9-4E27-A561-90816AFCEE2EQ35787126-00856E18-781F-4CCE-9112-3897E584FC44Q36436472-624EE402-D89A-4623-AF3A-83C9A6B80300Q37280509-4B455388-5D2B-41C2-B3FE-26DFA831B480Q37755990-4F9B16DB-3FFD-4ED8-A4A1-3FA6D2C0BC0EQ40069459-FC078254-7707-48FA-B8D0-420738E95600Q40158538-1910A2D7-98FA-457A-A9B3-456C2636AE5AQ40484843-2FB571AA-A55C-41A7-BA8D-F2D05CE6F9E9Q40762306-8B6CEDA4-69C2-4E92-A530-5DB00BDB5BAFQ42345389-38EAEB44-FAA9-4D70-AB8D-4FB143A1D956Q42687946-C4B19616-432A-4D02-9946-A14CB4D56D12Q43624026-9478BC95-FFAC-4533-BE33-1514CA2D506DQ47230575-9F6EE69D-8B86-45C8-8A45-7214F1472583Q48250984-FAED1188-2868-40D6-9B2D-876EFC2A2903Q48532943-B39C3259-0B64-4B7D-A7E6-872F248FC5A6Q48534664-7E99BF56-DD5E-4B6C-97CA-3D9239AC4CF9
P2860
Rapid and slow voltage-dependent conformational changes in segment IVS6 of voltage-gated Na(+) channels
description
2000 nî lūn-bûn
@nan
2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Rapid and slow voltage-depende ...... gment IVS6 of voltage-gated Na
@nl
Rapid and slow voltage-depende ...... f voltage-gated Na(+) channels
@ast
Rapid and slow voltage-depende ...... f voltage-gated Na(+) channels
@en
type
label
Rapid and slow voltage-depende ...... gment IVS6 of voltage-gated Na
@nl
Rapid and slow voltage-depende ...... f voltage-gated Na(+) channels
@ast
Rapid and slow voltage-depende ...... f voltage-gated Na(+) channels
@en
prefLabel
Rapid and slow voltage-depende ...... gment IVS6 of voltage-gated Na
@nl
Rapid and slow voltage-depende ...... f voltage-gated Na(+) channels
@ast
Rapid and slow voltage-depende ...... f voltage-gated Na(+) channels
@en
P2860
P1433
P1476
Rapid and slow voltage-depende ...... f voltage-gated Na(+) channels
@en
P2093
S C Cannon
P2860
P304
P356
10.1016/S0006-3495(00)76834-2
P407
P577
2000-06-01T00:00:00Z