Identification of the viral genes responsible for growth of strains of reovirus in cultured mouse heart cells.
about
Comparisons of the M1 genome segments and encoded mu2 proteins of different reovirus isolatesThe M1 gene is associated with differences in the temperature optimum of the transcriptase activity in reovirus core particlesReovirus induction of and sensitivity to beta interferon in cardiac myocyte cultures correlate with induction of myocarditis and are determined by viral core proteins.Reovirus core protein mu2 determines the filamentous morphology of viral inclusion bodies by interacting with and stabilizing microtubules.A post-entry step in the mammalian orthoreovirus replication cycle is a determinant of cell tropism.Reovirus-induced acute myocarditis in mice correlates with viral RNA synthesis rather than generation of infectious virus in cardiac myocytes.Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by Bcl-2.Association of the reovirus S1 gene with serotype 3-induced biliary atresia in mice.Multiple viral core proteins are determinants of reovirus-induced acute myocarditis.Identification of functional domains in reovirus replication proteins muNS and mu2.Identification and characterization of a double-stranded RNA- reovirus temperature-sensitive mutant defective in minor core protein mu2Core protein mu2 is a second determinant of nucleoside triphosphatase activities by reovirus cores.Increased ubiquitination and other covariant phenotypes attributed to a strain- and temperature-dependent defect of reovirus core protein mu2.Studies of the major reovirus core protein sigma 2: reversion of the assembly-defective mutant tsC447 is an intragenic process and involves back mutation of Asp-383 to Asn.Dissection of mammalian orthoreovirus µ2 reveals a self-associative domain required for binding to microtubules but not to factory matrix protein µNS.Silencing and complementation of reovirus core protein mu2: functional correlations with mu2-microtubule association and differences between virus- and plasmid-derived mu2.The reovirus M1 gene determines the relative capacity of growth of reovirus in cultured bovine aortic endothelial cells.Inhibition of reovirus by mycophenolic acid is associated with the M1 genome segment.Junctional adhesion molecule-A is required for hematogenous dissemination of reovirusSuppression of cytokines and nitric oxide production, and protection against lethal endotoxemia and viral myocarditis by a new NF-kappaB inhibitor.
P2860
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P2860
Identification of the viral genes responsible for growth of strains of reovirus in cultured mouse heart cells.
description
1991 nî lūn-bûn
@nan
1991 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Identification of the viral ge ...... in cultured mouse heart cells.
@ast
Identification of the viral ge ...... in cultured mouse heart cells.
@en
Identification of the viral ge ...... in cultured mouse heart cells.
@nl
type
label
Identification of the viral ge ...... in cultured mouse heart cells.
@ast
Identification of the viral ge ...... in cultured mouse heart cells.
@en
Identification of the viral ge ...... in cultured mouse heart cells.
@nl
prefLabel
Identification of the viral ge ...... in cultured mouse heart cells.
@ast
Identification of the viral ge ...... in cultured mouse heart cells.
@en
Identification of the viral ge ...... in cultured mouse heart cells.
@nl
P2093
P2860
P356
P1476
Identification of the viral ge ...... in cultured mouse heart cells.
@en
P2093
P2860
P304
P356
10.1172/JCI115177
P407
P577
1991-05-01T00:00:00Z