The reovirus M1 gene, encoding a viral core protein, is associated with the myocarditic phenotype of a reovirus variant
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Comparisons of the M1 genome segments and encoded mu2 proteins of different reovirus isolatesDiminished reovirus capsid stability alters disease pathogenesis and littermate transmissionThe M1 gene is associated with differences in the temperature optimum of the transcriptase activity in reovirus core particlesProteomic analysis reveals virus-specific Hsp25 modulation in cardiac myocytes.The reovirus protein mu2, encoded by the M1 gene, is an RNA-binding protein.Basal and reovirus-induced beta interferon (IFN-beta) and IFN-beta-stimulated gene expression are cell type specific in the cardiac protective response.Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease.Reovirus induction of and sensitivity to beta interferon in cardiac myocyte cultures correlate with induction of myocarditis and are determined by viral core proteins.Reovirus core protein mu2 determines the filamentous morphology of viral inclusion bodies by interacting with and stabilizing microtubules.Identification of the viral genes responsible for growth of strains of reovirus in cultured mouse heart cells.Rotavirus genome segment 7 (NSP3) is a determinant of extraintestinal spread in the neonatal mouse.Reovirus receptors and pathogenesis.A single-amino-acid polymorphism in reovirus protein μ2 determines repression of interferon signaling and modulates myocarditisGenetic mapping of reovirus virulence and organ tropism in severe combined immunodeficient mice: organ-specific virulence genes.Brain- and intestine-specific variants of reovirus serotype 3 strain dearing are selected during chronic infection of severe combined immunodeficient micePersistent reovirus infections of L cells select mutations in viral attachment protein sigma1 that alter oligomer stabilityReovirus-induced acute myocarditis in mice correlates with viral RNA synthesis rather than generation of infectious virus in cardiac myocytes.Linkage between reovirus-induced apoptosis and inhibition of cellular DNA synthesis: role of the S1 and M2 genes.Reovirus-induced apoptosis of MDCK cells is not linked to viral yield and is blocked by Bcl-2.Multiple viral core proteins are determinants of reovirus-induced acute myocarditis.Murine rotavirus genes encoding outer capsid proteins VP4 and VP7 are not major determinants of host range restriction and virulenceLymphocytes protect against and are not required for reovirus-induced myocarditis.Inhibition of NF-kappa B activity and cFLIP expression contribute to viral-induced apoptosis.Derivation and characterization of an efficiently myocarditic reovirus variant.Cardiac cell-specific apoptotic and cytokine responses to reovirus infection: determinants of myocarditic phenotype.Rotavirus and reovirus modulation of the interferon response.Immunohistochemical detection of piscine reovirus (PRV) in hearts of Atlantic salmon coincide with the course of heart and skeletal muscle inflammation (HSMI).Identification and characterization of a double-stranded RNA- reovirus temperature-sensitive mutant defective in minor core protein mu2Core protein mu2 is a second determinant of nucleoside triphosphatase activities by reovirus cores.Increased ubiquitination and other covariant phenotypes attributed to a strain- and temperature-dependent defect of reovirus core protein mu2.Studies of the major reovirus core protein sigma 2: reversion of the assembly-defective mutant tsC447 is an intragenic process and involves back mutation of Asp-383 to Asn.Cytopathogenic effect in cardiac myocytes but not in cardiac fibroblasts is correlated with reovirus-induced acute myocarditis.Dissection of mammalian orthoreovirus µ2 reveals a self-associative domain required for binding to microtubules but not to factory matrix protein µNS.Spontaneous activation of a MAVS-dependent antiviral signaling pathway determines high basal interferon-β expression in cardiac myocytes.The reovirus M1 gene determines the relative capacity of growth of reovirus in cultured bovine aortic endothelial cells.Inhibition of reovirus by mycophenolic acid is associated with the M1 genome segment.Reovirus mu2 protein inhibits interferon signaling through a novel mechanism involving nuclear accumulation of interferon regulatory factor 9.Protein Mismatches Caused by Reassortment Influence Functions of the Reovirus Capsid
P2860
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P2860
The reovirus M1 gene, encoding a viral core protein, is associated with the myocarditic phenotype of a reovirus variant
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
The reovirus M1 gene, encoding ...... henotype of a reovirus variant
@en
type
label
The reovirus M1 gene, encoding ...... henotype of a reovirus variant
@en
prefLabel
The reovirus M1 gene, encoding ...... henotype of a reovirus variant
@en
P2860
P1433
P1476
The reovirus M1 gene, encoding ...... henotype of a reovirus variant
@en
P2093
P2860
P304
P407
P577
1989-11-01T00:00:00Z