HERG channel (dys)function revealed by dynamic action potential clamp technique
about
Rescue of aberrant gating by a genetically encoded PAS (Per-Arnt-Sim) domain in several long QT syndrome mutant human ether-á-go-go-related gene potassium channelsComputer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challengesNew aspects of HERG K⁺ channel function depending upon cardiac spatial heterogeneityThe past, present, and future of real-time control in cellular electrophysiology.The S1 helix critically regulates the finely tuned gating of Kv11.1 channelsA computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current.Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channelsMouse ERG K(+) channel clones reveal differences in protein trafficking and function.Models of HERG gatingKinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel.Dynamic clamp with StdpC software.Rapid genetic algorithm optimization of a mouse computational model: benefits for anthropomorphization of neonatal mouse cardiomyocytesWild type and K897T polymorphisms of the hERG gene: modeling the APD in Caucasians.Dynamic clamp analyses of cardiac, endocrine, and neural function.Dynamic clamp: a powerful tool in cardiac electrophysiology.MATLAB implementation of a dynamic clamp with bandwidth of >125 kHz capable of generating I Na at 37 °C.Mechanistic basis for type 2 long QT syndrome caused by KCNH2 mutations that disrupt conserved arginine residues in the voltage sensor.A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cellsLQT2 nonsense mutations generate trafficking defective NH2-terminally truncated channels by the reinitiation of translation.Anthropomorphizing the mouse cardiac action potential via a novel dynamic clamp method.HERG potassium channel regulation by the N-terminal eag domain.Molecular Pathophysiology of Congenital Long QT Syndrome.Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique.Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations.Dynamical mechanisms of pacemaker generation in IK1-downregulated human ventricular myocytes: insights from bifurcation analyses of a mathematical model.Markov models for ion channels: versatility versus identifiability and speed.Shaping a new Ca²⁺ conductance to suppress early afterdepolarizations in cardiac myocytes.Contributions of inwardly rectifying K+ currents to repolarization assessed using mathematical models of human ventricular myocytes.Quantitative prediction of the arrhythmogenic effects of de novo hERG mutations in computational models of human ventricular tissues.Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing.Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility.Trafficking defects in PAS domain mutant Kv11.1 channels: roles of reduced domain stability and altered domain-domain interactions.Simultaneous recording of electrical activity and the underlying ionic currents in NG108-15 cells cultured on gold substrate.Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study.Dynamic action potential clamp predicts functional separation in mild familial and severe de novo forms of epilepsy
P2860
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P2860
HERG channel (dys)function revealed by dynamic action potential clamp technique
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
HERG channel (dys)function revealed by dynamic action potential clamp technique
@ast
HERG channel (dys)function revealed by dynamic action potential clamp technique
@en
HERG channel
@nl
type
label
HERG channel (dys)function revealed by dynamic action potential clamp technique
@ast
HERG channel (dys)function revealed by dynamic action potential clamp technique
@en
HERG channel
@nl
prefLabel
HERG channel (dys)function revealed by dynamic action potential clamp technique
@ast
HERG channel (dys)function revealed by dynamic action potential clamp technique
@en
HERG channel
@nl
P2093
P2860
P1433
P1476
HERG channel (dys)function revealed by dynamic action potential clamp technique
@en
P2093
Antoni C G van Ginneken
Berend de Jonge
Géza Berecki
Jan G Zegers
Marieke W Veldkamp
Ronald Wilders
Zahurul A Bhuiyan
P2860
P304
P356
10.1529/BIOPHYSJ.104.047290
P407
P577
2004-10-08T00:00:00Z