Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter
about
Biology of the major facilitative folate transporters SLC19A1 and SLC46A1The proton-coupled folate transporter: physiological and pharmacological roles.Identification and functional impact of homo-oligomers of the human proton-coupled folate transporter.The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporterFolate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors.Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transIntestinal transport of aminopterin enantiomers in dogs and humans with psoriasis is stereoselective: evidence for a mechanism involving the proton-coupled folate transporter.Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter.Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1)Expression in Sf9 insect cells, purification and functional reconstitution of the human proton-coupled folate transporter (PCFT, SLC46A1).6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human TumorsNovel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents.Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates.Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method.Inhibition of the proton-coupled folate transporter (PCFT-SLC46A1) by bicarbonate and other anions.Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter.The antifolatesTumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide BiosyTumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6-7 linker.Enhanced receptor-mediated endocytosis and cytotoxicity of a folic acid-desacetylvinblastine monohydrazide conjugate in a pemetrexed-resistant cell line lacking folate-specific facilitative carriers but with increased folate receptor expressionThe major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.Dual Targeting of Epithelial Ovarian Cancer Via Folate Receptor α and the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates.Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest.Folic Acid Impairs the Uptake of 5-Methyltetrahydrofolate in Human Umbilical Vascular Endothelial Cells.The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer.Concentrative transport of antifolates mediated by the proton-coupled folate transporter (PCFT, SLC46A1); augmentation by a HEPES buffer.Development and validation of chemical features-based proton-coupled folate transporter/activity and reduced folate carrier/activity models (pharmacophores).Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
P2860
Q26998717-CBC6D833-D56D-4C66-BB39-C2CBFD1098D2Q33908502-EEA7D4AB-D82B-4D77-95E3-BA6C69FE53D3Q34241413-21E3E0FD-B2C7-4533-870D-D86344C2045BQ34297931-EE801EF1-185D-4450-89F3-7F85B34B2697Q34313771-CE69547F-8D29-4FEE-B14A-40263A2CB6C6Q34333704-520AB71E-2BC2-420F-9E75-7F3CE596CA6BQ34471848-E92F9D68-22B0-4F8F-8FA5-CF957891E3D5Q35783179-9AEF9694-9226-46B6-BAB7-7E2C8A484F0CQ36174195-ACCF8F99-1AA7-4175-9C83-D9FE6143FF17Q36294436-200AD2E7-8402-4171-B52A-768605A3C800Q36308965-8ED842CD-E17E-400B-A56C-830CCC47BEA5Q36369109-A2F01CCB-76C4-4F5E-80FD-B80361320C05Q36467564-39C21AD1-7343-4399-86F0-56C0F6D503FFQ36467569-9A37A203-E2B9-4252-AA9B-FE9016A8C217Q36733474-6A1FD551-A32E-457E-8816-F614CFB493CDQ36923565-7B442113-0B68-4BB0-B671-121647F958BEQ36935269-120258B2-34C5-4217-BDA2-91FFA98CDECEQ37162634-B3AD3F64-187F-4594-BD89-B181555B70EFQ37183495-A69D3E6C-721D-409C-B722-7DAA8449A9A0Q37246257-793C9696-0E84-4863-ACFE-933A07A1D56CQ37432606-EA54B947-4D75-41A8-A09D-25BAD9830676Q37546123-8C834A96-11BB-4CF3-9E36-CD55DD3F7BACQ37553497-91783054-37FE-4C65-AD1B-2CBE15DE1DFDQ37663377-305CCD29-664C-4B7E-A65A-381E97746C19Q38718741-07B0C640-C16B-4875-8962-385781C075E5Q42003221-90085377-77EB-4678-AAB1-BCDE030CF08AQ42699149-97826495-371B-49FF-A01E-3ACCE5717962Q50062142-67B90F83-3076-4F6C-9BCA-581056774C73Q50077775-A88B25D3-98DB-4075-B60F-15AD815AA561Q51730395-78AE1AF1-2CC5-49AA-BCBD-1125AB108CABQ52559376-431A876D-67A4-41B9-A42D-32726946A5E5
P2860
Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Therapeutic targeting of a nov ...... ton-coupled folate transporter
@ast
Therapeutic targeting of a nov ...... ton-coupled folate transporter
@en
Therapeutic targeting of a nov ...... ton-coupled folate transporter
@nl
type
label
Therapeutic targeting of a nov ...... ton-coupled folate transporter
@ast
Therapeutic targeting of a nov ...... ton-coupled folate transporter
@en
Therapeutic targeting of a nov ...... ton-coupled folate transporter
@nl
prefLabel
Therapeutic targeting of a nov ...... ton-coupled folate transporter
@ast
Therapeutic targeting of a nov ...... ton-coupled folate transporter
@en
Therapeutic targeting of a nov ...... ton-coupled folate transporter
@nl
P2093
P2860
P356
P1476
Therapeutic targeting of a nov ...... ton-coupled folate transporter
@en
P2093
Aleem Gangjee
Christina Cherian
Eric Hales
Juiwanna Kushner
Kathryn White
Larry H Matherly
Lisa Polin
Mark Stout
Sita Kugel Desmoulin
P2860
P304
P356
10.1124/MOL.111.073833
P577
2011-09-22T00:00:00Z