Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast.
about
Modeling signal propagation mechanisms and ligand-based conformational dynamics of the Hsp90 molecular chaperone full-length dimerA two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p).The co-chaperone Hch1 regulates Hsp90 function differently than its homologue Aha1 and confers sensitivity to yeast to the Hsp90 inhibitor NVP-AUY922Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative diseaseEffect of mutation of the tetratricopeptide repeat and asparatate-proline 2 domains of Sti1 on Hsp90 signaling and interaction in Saccharomyces cerevisiaeThe Hsp90 chaperone complex regulates GDI-dependent Rab recyclingCasein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity.The yeast Hsp70 Ssa1 is a sensor for activation of the heat shock response by thiol-reactive compounds.Fungal heat-shock proteins in human disease.Heat shock protein 70 (Hsp70) inhibits oxidative phosphorylation and compensates ATP balance through enhanced glycolytic activity.p23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activityMolecular chaperones in pathogen virulence: emerging new targets for therapy.Co-chaperones of Hsp90 in Plasmodium falciparum and their concerted roles in cellular regulation.Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges.Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinaseInsights from yeast into whether the inhibition of heat shock transcription factor (Hsf1) by rapamycin can prevent the Hsf1 activation that results from treatment with an Hsp90 inhibitor.Adapting to stress - chaperome networks in cancer.The Paralogous Genes and , Encoding Multidrug Resistance ABC Transporters, Derive From a Recent Duplication Event, Being Specific to the Genus
P2860
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P2860
Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast.
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Sensitivity to Hsp90-targeting ...... assette transporters of yeast.
@ast
Sensitivity to Hsp90-targeting ...... assette transporters of yeast.
@en
Sensitivity to Hsp90-targeting ...... assette transporters of yeast.
@nl
type
label
Sensitivity to Hsp90-targeting ...... assette transporters of yeast.
@ast
Sensitivity to Hsp90-targeting ...... assette transporters of yeast.
@en
Sensitivity to Hsp90-targeting ...... assette transporters of yeast.
@nl
prefLabel
Sensitivity to Hsp90-targeting ...... assette transporters of yeast.
@ast
Sensitivity to Hsp90-targeting ...... assette transporters of yeast.
@en
Sensitivity to Hsp90-targeting ...... assette transporters of yeast.
@nl
P2093
P2860
P1433
P1476
Sensitivity to Hsp90-targeting ...... assette transporters of yeast.
@en
P2093
Barry Panaretou
Giuliano Siligardi
Laurence H Pearl
Mehdi Mollapour
Peter W Piper
P2860
P304
P356
10.1046/J.1432-1033.2003.03866.X
P407
P577
2003-12-01T00:00:00Z