A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
about
Stabilizing versus destabilizing the microtubules: a double-edge sword for an effective cancer treatment option?Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discoveryPre-clinical evaluation of a novel class of anti-cancer agents, the Pyrrolo-1, 5-benzoxazepinesHigh-affinity accumulation of a maytansinoid in cells via weak tubulin interaction.Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-MitoticsUner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stabilitySynthesis and Cytotoxicity Evaluation of C4- and C5-Modified Analogues of the α,β-Unsaturated Lactone of PironetinA previously undescribed tubulin binderThe design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.A Novel Microtubule-Disrupting Agent Induces Endoplasmic Reticular Stress-Mediated Cell Death in Human Hepatocellular Carcinoma Cells.Structures of potent anticancer compounds bound to tubulin11-Substituted Benzo[c]phenanthridines: New Structures and Insight into Their Mode of Antiproliferative Action.Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based DesignEribulin targets a ch-TOG-dependent directed migration of cancer cellsCentriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth.Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubuleControl of microtubule organization and dynamics: two ends in the limelight.Biosynthesis of polyketides by trans-AT polyketide synthases.Design, synthesis, and structure-activity relationships of pyrimido[4,5-b]indole-4-amines as microtubule depolymerizing agents that are effective against multidrug resistant cells.Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin.Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells.Synthesis and evaluation of hybrid molecules targeting the vinca domain of tubulin.Strategies and challenges for the next generation of antibody-drug conjugates.Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies.Rhizoxin analogs, orfamide A and chitinase production contribute to the toxicity of Pseudomonas protegens strain Pf-5 to Drosophila melanogaster.Marine Sponge Natural Products with Anticancer Potential: An Updated Review.Synthesis and Biological Evaluation of Benzocyclooctene-based and Indene-based Anticancer Agents that Function as Inhibitors of Tubulin Polymerization.Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes.Structure-based approaches for the design of benzimidazole-2-carbamate derivatives as tubulin polymerization inhibitors.Microtubule Depolymerization by Kinase Inhibitors: Unexpected Findings of Dual Inhibitors.Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells.High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design.Structure based drug design and in vitro metabolism study: Discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent.Molecular basis of resistance to the microtubule-depolymerizing antitumor compound plocabulin.A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.DNA damaging agent-based antibody-drug conjugates for cancer therapyDrug–tubulin interactions interrogated by transient absorption spectroscopyTargeting B Cell Maturation Antigen (BCMA) in Multiple Myeloma: Potential Uses of BCMA-Based Immunotherapy
P2860
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P2860
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
description
2014 nî lūn-bûn
@nan
2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
A new tubulin-binding site and ...... destabilizing anticancer drugs
@ast
A new tubulin-binding site and ...... destabilizing anticancer drugs
@en
A new tubulin-binding site and ...... destabilizing anticancer drugs
@nl
type
label
A new tubulin-binding site and ...... destabilizing anticancer drugs
@ast
A new tubulin-binding site and ...... destabilizing anticancer drugs
@en
A new tubulin-binding site and ...... destabilizing anticancer drugs
@nl
prefLabel
A new tubulin-binding site and ...... destabilizing anticancer drugs
@ast
A new tubulin-binding site and ...... destabilizing anticancer drugs
@en
A new tubulin-binding site and ...... destabilizing anticancer drugs
@nl
P2093
P2860
P50
P356
P1476
A new tubulin-binding site and ...... destabilizing anticancer drugs
@en
P2093
Andrea E Prota
Carmen Cuevas
Christian Neuhaus
Jose M Andreu
Karl-Heinz Altmann
Katja Bargsten
P2860
P304
13817-13821
P356
10.1073/PNAS.1408124111
P407
P577
2014-08-11T00:00:00Z