Mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development - Wikidata - awgldk - TriplyDB

Mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development

Mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development

http://www.wikidata.org/entity/Q34281452

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Characterization and review of MTHFD1 deficiency: four new patients, cellular delineation and response to folic and folinic acid treatment Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls Biomarkers of Nutrition for Development-Folate Review Modeling cellular compartmentation in one-carbon metabolism Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos Mammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissues Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice Mitochondrial dysfunction remodels one-carbon metabolism in human cells Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase.dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective.A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1.The role of mitochondrial DNA copy number in mammalian fertility.Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.Disruption of the folate pathway in zebrafish causes developmental defects Folic acid in early pregnancy: a public health success story Disruption of the mthfd1 gene reveals a monofunctional 10-formyltetrahydrofolate synthetase in mammalian mitochondria.Unraveling the association between mRNA expressions and mutant phenotypes in a genome-wide assessment of mice.Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway Leber hereditary optic neuropathy: do folate pathway gene alterations influence the expression of mitochondrial DNA mutation?Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major.Genetic variation in the one-carbon transfer pathway and ovarian cancer risk.Genetic and epigenomic footprints of folate.Trafficking of intracellular folates.Mitochondrial one-carbon metabolism and neural tube defects.Give it or take it: the flux of one-carbon in cancer cells.One-Carbon Metabolism in Health and Disease.Mammalian fibroblasts lacking mitochondrial NAD+-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase are glycine auxotrophs.Mutations in genes encoding the glycine cleavage system predispose to neural tube defects in mice and humans.The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism.Role of polymorphisms in MTHFR and MTHFD1 genes in the outcome of childhood acute lymphoblastic leukemia.Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.Increased formate overflow is a hallmark of oxidative cancer.Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation Insights into the Etiology of Mammalian Neural Tube Closure Defects from Developmental, Genetic and Evolutionary Studies

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Mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development

http://www.wikidata.org/entity/Q34281452

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2002 nî lūn-bûn

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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2002年の論文

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Molecular and Cellular Biology

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Mitochondrial NAD-dependent me ...... tial for embryonic development

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Di Pietro E

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MacKenzie RE

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Sirois J

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Tremblay ML

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P2860

Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure

NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is the mammalian homolog of the mitochondrial enzyme encoded by the yeast MIS1 gene

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Regulation of the balance of one-carbon metabolism in Saccharomyces cerevisiae.

Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae.

Initiation of protein synthesis in Saccharomyces cerevisiae mitochondria without formylation of the initiator tRNA.

Purification and characterization of a mitochondrial isozyme of C1-tetrahydrofolate synthase from Saccharomyces cerevisiae

Metabolic role of cytoplasmic isozymes of 5,10-methylenetetrahydrofolate dehydrogenase in Saccharomyces cerevisiae.

NAD-dependent methylenetetrahydrofolate dehydrogenase is expressed by immortal cells

Rat C1-tetrahydrofolate synthase. cDNA isolation, tissue-specific levels of the mRNA, and expression of the protein in yeast

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4158-4166

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10.1128/MCB.22.12.4158-4166.2002

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