Mammalian fibroblasts lacking mitochondrial NAD+-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase are glycine auxotrophs.
about
Mitochondrial Dysfunction in Cancer and Neurodegenerative Diseases: Spotlight on Fatty Acid Oxidation and Lipoperoxidation ProductsMitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryosMammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissuesMitochondrial dysfunction remodels one-carbon metabolism in human cellsMagnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase.Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.Disruption of the mthfd1 gene reveals a monofunctional 10-formyltetrahydrofolate synthetase in mammalian mitochondria.Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism.Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in miceReversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate PathwayMetabolite profiling identifies a key role for glycine in rapid cancer cell proliferationTargeting MTHFD2 in acute myeloid leukemiaMethylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major.Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolismMitochondrial one-carbon metabolism and neural tube defects.One-Carbon Metabolism in Health and Disease.The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism.Mitochondrial Methylenetetrahydrofolate Dehydrogenase (MTHFD2) Overexpression Is Associated with Tumor Cell Proliferation and Is a Novel Target for Drug Development.Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.Formate Promotes Intercellular Spread and Virulence Gene Expression
P2860
Q26767051-0BC21FFE-7EB8-4E0F-909D-94D73AFBFB6AQ28506233-E55447D4-B03F-45A1-A909-A74CAAA351F5Q28571107-1C2EC981-3DD4-4664-A927-3E4DF616A8CBQ28830026-85C62D50-0192-461C-9E45-4F8CE22C4F54Q30668561-D70C216E-9B3E-4CAD-9C40-5F0B0789BF12Q33931343-0F48D7F6-EDAD-47C3-9E64-71964138BB1CQ34378363-884A7DC6-BB24-4810-9873-15EF75099A03Q35801960-015B3582-30C5-492D-A16E-2442E67A7DE2Q35826415-BBF7AC99-40F8-47F0-94A7-2901F8287BCBQ36025884-A8C42908-0C3A-4EEE-977A-74E396F49532Q36477750-DAF1C2F4-528D-4D92-9FAA-A720F426DA2BQ37047306-96A6DF5C-0F8C-498D-8830-0BE5849C30CCQ37217438-E10F8369-7E18-480C-B376-39A1C5FAF028Q37455061-0F66CA22-D101-4214-A67C-702392B06B99Q38225378-B0491AC4-C03D-418C-B2CA-7ED67902C2A5Q38957946-494FDACC-98E2-4BD9-A640-159536334B64Q42427505-2BF37EE1-8864-493A-88F7-E6EF9DCD1C5CQ43203965-0ED60B44-BD69-4A27-A44C-FEF7DF1F35D8Q50089755-4D958774-4557-414B-BF20-7B1D37311548Q58699025-646DB740-604D-47EE-B504-2B0421540D10
P2860
Mammalian fibroblasts lacking mitochondrial NAD+-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase are glycine auxotrophs.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Mammalian fibroblasts lacking ...... rolase are glycine auxotrophs.
@en
type
label
Mammalian fibroblasts lacking ...... rolase are glycine auxotrophs.
@en
prefLabel
Mammalian fibroblasts lacking ...... rolase are glycine auxotrophs.
@en
P2093
P2860
P356
P1476
Mammalian fibroblasts lacking ...... rolase are glycine auxotrophs.
@en
P2093
Erminia Di Pietro
Harshila Patel
Robert E MacKenzie
P2860
P304
19436-19441
P356
10.1074/JBC.M301718200
P407
P577
2003-03-19T00:00:00Z