Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
about
ATM activation by ionizing radiation requires BRCA1-associated BAAT1ATM-dependent phosphorylation of ATF2 is required for the DNA damage responseWSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activityInteraction between human MCM7 and Rad17 proteins is required for replication checkpoint signalingSIRT1 regulates the function of the Nijmegen breakage syndrome proteinTargeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53RAD50 and NBS1 form a stable complex functional in DNA binding and tetheringInvolvement of human MOF in ATM functionFunctional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppressionImmunoglobulin class switch recombination is impaired in Atm-deficient miceCep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1DNA End Resection: Facts and MechanismsA Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage ResponseChromatin perturbations during the DNA damage response in higher eukaryotesThe role of poly(ADP-ribosyl)ation in DNA damage response and cancer chemotherapyThe Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesStructure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signalingStructural basis for DNA recognition and nuclease processing by the Mre11 homologue SbcD in double-strand breaks repairAtaxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.DNA-PK autophosphorylation facilitates Artemis endonuclease activityEnvisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairMRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length controlMRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage ResponseRAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function?The response to and repair of RAG-mediated DNA double-strand breaksA role for the Tip60 histone acetyltransferase in the acetylation and activation of ATMThe role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint controlAncient and recent adaptive evolution of primate non-homologous end joining genesHuman papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiationThe JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiationAn essential function for NBS1 in the prevention of ataxia and cerebellar defectsNibrin functions in Ig class-switch recombinationDouble strand break repair functions of histone H2AXConserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damageThe Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural OrganizationVariants in activators and downstream targets of ATM, radiation exposure, and contralateral breast cancer risk in the WECARE study.The yin-yang of DNA damage response: roles in tumorigenesis and cellular senescence.Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis.Autophosphorylation and ATM activation: additional sites add to the complexity.ATR and ATM regulate the timing of DNA replication origin firing.
P2860
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P2860
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
@ast
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
@en
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
@nl
type
label
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
@ast
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
@en
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
@nl
prefLabel
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
@ast
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
@en
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
@nl
P356
P1433
P1476
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
@en
P2093
Ji-Hoon Lee
Tanya T Paull
P356
10.1126/SCIENCE.1091496
P407
P577
2004-04-01T00:00:00Z