3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1. - Wikidata - awgldk - TriplyDB

3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.

3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.

http://www.wikidata.org/entity/Q34324901

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How ATP inhibits the open K(ATP) channel The Nucleotide-Binding Sites of SUR1: A Mechanistic Model KATP channels and cardiovascular disease: suddenly a syndrome A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes.A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults.β2-Adrenergic ion-channel coupled receptors as conformational motion detectors Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia The cystic fibrosis transmembrane conductance regulator (CFTR) and its stability Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel.Quaternary structure of KATP channel SUR2A nucleotide binding domains resolved by synchrotron radiation X-ray scattering.Human K(ATP) channelopathies: diseases of metabolic homeostasis.The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes ATP modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic beta-cell KATP channels N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2 Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes Muscle KATP channels: recent insights to energy sensing and myoprotection Neonatal Diabetes and Congenital Hyperinsulinism Caused by Mutations in ABCC8/SUR1 are Associated with Altered and Opposite Affinities for ATP and ADP Integrin α9β1-mediated cell migration in glioblastoma via SSAT and Kir4.2 potassium channel pathway Mechanism of KATP hyperactivity and sulfonylurea tolerance due to a diabetogenic mutation in L0 helix of sulfonylurea receptor 1 (ABCC8)On potential interactions between non-selective cation channel TRPM4 and sulfonylurea receptor SUR1.Engineered interaction between SUR1 and Kir6.2 that enhances ATP sensitivity in KATP channels.Kir6.2 activation by sulfonylurea receptors: a different mechanism of action for SUR1 and SUR2A subunits via the same residues.Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes.Insight in eukaryotic ABC transporter function by mutation analysis.Metabolic syndrome induces changes in KATP-channels and calcium currents in pancreatic β-cells.From molecule to malady.Domain organization of the ATP-sensitive potassium channel complex examined by fluorescence resonance energy transfer.The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel New insight into the biochemical mechanisms regulating auxin transport in plants.Electrophysiology properties of voltage-gated potassium channels in rat peritoneal macrophages Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator.Interaction of asymmetric ABCC9-encoded nucleotide binding domains determines KATP channel SUR2A catalytic activity.Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels.The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system The unusual stoichiometry of ADP activation of the KATP channel.Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating.The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet.K(+) channels: function-structural overview.

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3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.

http://www.wikidata.org/entity/Q34324901

description

2005 nî lūn-bûn

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2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2005 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

3-D structural and functional ...... P channel complex Kir6.2-SUR1.

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3-D structural and functional ...... P channel complex Kir6.2-SUR1.

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3-D structural and functional ...... P channel complex Kir6.2-SUR1.

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type

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3-D structural and functional ...... P channel complex Kir6.2-SUR1.

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3-D structural and functional ...... P channel complex Kir6.2-SUR1.

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3-D structural and functional ...... P channel complex Kir6.2-SUR1.

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3-D structural and functional ...... P channel complex Kir6.2-SUR1.

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3-D structural and functional ...... P channel complex Kir6.2-SUR1.

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3-D structural and functional ...... P channel complex Kir6.2-SUR1.

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SJ.EMBOJ.7600877

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The EMBO Journal

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3-D structural and functional ...... P channel complex Kir6.2-SUR1.

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P2093

Frances M Ashcroft

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Jeff D Campbell

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Kenju Shimomura

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Mark S P Sansom

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Michael V Mikhailov

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Richard F Collins

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P2860

Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features

M-LDH serves as a sarcolemmal K(ATP) channel subunit essential for cell protection against ischemia

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution

Crystal structure of the potassium channel KirBac1.1 in the closed state

A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle

Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator

UCSF Chimera--a visualization system for exploratory research and analysis

EMAN: semiautomated software for high-resolution single-particle reconstructions

Potassium channel regulation.

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4166-4175

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scholarly article

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10.1038/SJ.EMBOJ.7600877

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23

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24

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Brittany Z Dashevsky

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2005-11-24T00:00:00Z

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P5875

7459537

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16308567

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P921

ATP-sensitive potassium channel complex

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1356316

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