Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold
about
Macrocyclic histone deacetylase inhibitorsStructural Basis of the Antiproliferative Activity of Largazole, a Depsipeptide Inhibitor of the Histone DeacetylasesLargazole and its derivatives selectively inhibit ubiquitin activating enzyme (e1)Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides.Biological evaluation of new largazole analogues: alteration of macrocyclic scaffold with click chemistry.Potent and orally efficacious bisthiazole-based histone deacetylase inhibitorsEvaluation of class I HDAC isoform selectivity of largazole analoguesSynthesis and biological evaluation of largazole analogues with modified surface recognition cap groupsComputational exploration of zinc binding groups for HDAC inhibitionIn Vitro and In Vivo Osteogenic Activity of Largazole.Comparative pharmacokinetic properties and antitumor activity of the marine HDACi Largazole and Largazole peptide isostereNatural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism.Variable active site loop conformations accommodate the binding of macrocyclic largazole analogues to HDAC8Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes.Modular synthesis and biological activity of pyridyl-based analogs of the potent Class I Histone Deacetylase Inhibitor Largazole.Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agentsLargazole: from discovery to broad-spectrum therapy.Discovery and mechanism of natural products as modulators of histone acetylation.Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs.Discovery, biological activity, synthesis and potential therapeutic utility of naturally occurring histone deacetylase inhibitors.Probing the biology of natural products: molecular editing by diverted total synthesis.Thiazole and oxazole alkaloids: isolation and synthesis.Synthesis and biological evaluation of largazole zinc-binding group analogs.Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation.Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes.Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis.Concise total synthesis of largazole.Microwave-assisted synthesis and antitumor evaluation of a new series of thiazolylcoumarin derivatives.Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue.Largazole Analogues as Histone Deacetylase Inhibitors and Anticancer Agents: An Overview of Structure-Activity Relationships.Total synthesis of (18S)- and (18R)-homolargazole by rhodium-catalyzed hydrocarboxylation.
P2860
Q24629065-1B67ADFA-2988-4E12-BFDE-8721F168650DQ27671010-D74DE97F-3672-4018-8549-D7065C3D620FQ28258201-56AD6F6F-6B42-47A2-A8B9-A69C3EEEB6C7Q33496543-954F5641-DAC1-4FE6-9267-33FAFD5D196DQ33636013-7189CBF5-FAAD-4BCA-9B7E-241D50ABB9D6Q33768549-B863AF7C-57F4-4129-83FD-3A4DDDC59075Q34054267-C091ED6B-B33B-4516-B2C9-6F7C14A7B6FDQ34302247-848558BF-FAEB-4702-A2F3-58CD8B0C2FCDQ34668407-B68897D0-FE65-4990-95CE-6749B655CDFEQ35030533-625618BD-21C3-49E0-B916-75A160D9B1DDQ35202369-BD5D4921-A1A0-4756-9752-4A88E6A517FEQ35215703-65D65591-00C3-49F6-805C-1E5DEBDD33E9Q35243482-D1538486-50D9-49DF-8850-5E624429B8FEQ35597103-4B828904-63E0-42C0-A534-D5249DF62D2BQ35656966-AC06CA18-EC63-495F-8DA0-925A3218AE56Q35733719-A6BE0BF3-D7C2-409D-B06D-85300A92154EQ36649018-13CFD2DC-C71B-469F-92B3-8AD3166A5CC1Q37242496-62FEF236-8E52-4E27-ADB9-DCF344C86A45Q37383739-3DC97061-9145-46BF-9763-4A13631B8D6DQ37603074-647BBB55-E750-4E72-B6C8-4FC914262E31Q37809500-8332852B-CCA2-4327-822F-5C1F69D56087Q37817756-C09D4634-BDEA-400B-B3C7-66445ABAFAFBQ38707248-9A13B609-E20D-487D-A075-C4A7F3398EA9Q38939048-BFFB75F2-333C-44AD-B6CA-DF70A37B7A6FQ38982458-AC0FBBF1-5D9C-4FEE-A381-C7E2AC27428AQ39606523-61D5613C-1EBA-4E2E-8609-4D6E89FBCE8EQ42828205-409B8894-CDF8-4061-9ACB-B585438C580DQ47133466-A6A0A619-A03F-40D4-B4F2-32950021DCD3Q47154262-C4B76904-E2D5-414C-82A9-895680717E87Q47631371-D715245D-49F4-4D64-B599-15B71F66CECBQ51755936-7A376D46-F27D-4C5A-8A78-336E358843CE
P2860
Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Synthesis and histone deacetyl ...... omain and macrocyclic scaffold
@en
Synthesis and histone deacetyl ...... main and macrocyclic scaffold.
@nl
type
label
Synthesis and histone deacetyl ...... omain and macrocyclic scaffold
@en
Synthesis and histone deacetyl ...... main and macrocyclic scaffold.
@nl
prefLabel
Synthesis and histone deacetyl ...... omain and macrocyclic scaffold
@en
Synthesis and histone deacetyl ...... main and macrocyclic scaffold.
@nl
P2093
P2860
P356
P1433
P1476
Synthesis and histone deacetyl ...... omain and macrocyclic scaffold
@en
P2093
Albert A Bowers
Annie E Troutman-Youngman
James E Bradner
Nathan West
Olaf Wiest
Robert M Williams
Stuart L Schreiber
Tenaya L Newkirk
P2860
P304
P356
10.1021/OL900078K
P407
P577
2009-03-01T00:00:00Z