The rate of bipolar spindle assembly depends on the microtubule-gliding velocity of the mitotic kinesin Eg5.
about
Kinesin-5: cross-bridging mechanism to targeted clinical therapyA nonmotor microtubule binding site in kinesin-5 is required for filament crosslinking and slidingPathway of ATP hydrolysis by monomeric kinesin Eg5Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitroA structural model for monastrol inhibition of dimeric kinesin Eg5.Kinesin-5/Eg5 is important for transport of CARTS from the trans-Golgi network to the cell surface.Kinesin-5 inhibitor resistance is driven by kinesin-12The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks.Phosphorylation by Cdk1 increases the binding of Eg5 to microtubules in vitro and in Xenopus egg extract spindlesStructural maintenance of chromosome (SMC) proteins link microtubule stability to genome integrity.Allosteric inhibition of kinesin-5 modulates its processive directional motility.Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysisEmergent Properties of the Metaphase Spindle.Load-dependent release limits the processive stepping of the tetrameric Eg5 motor.Cep57, a NEDD1-binding pericentriolar material component, is essential for spindle pole integrity.Getting in sync with dimeric Eg5. Initiation and regulation of the processive run.To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5.A chimeric kinesin-1 head/kinesin-5 tail motor switches between diffusive and processive motilityCentriole inheritanceMicrotubule motors in eukaryotic spindle assembly and maintenanceCurcumin suppresses the dynamic instability of microtubules, activates the mitotic checkpoint and induces apoptosis in MCF-7 cells.Directionality of individual kinesin-5 Cin8 motors is modulated by loop 8, ionic strength and microtubule geometry.Disjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomes.Cooperation Between Kinesin Motors Promotes Spindle Symmetry and Chromosome Organization in Oocytes.Synergistic Anticancer Effect of Peptide-Docetaxel Nanoassembly Targeted to Tubulin: Toward Development of Dual Warhead Containing Nanomedicine.
P2860
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P2860
The rate of bipolar spindle assembly depends on the microtubule-gliding velocity of the mitotic kinesin Eg5.
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The rate of bipolar spindle as ...... ty of the mitotic kinesin Eg5.
@ast
The rate of bipolar spindle as ...... ty of the mitotic kinesin Eg5.
@en
The rate of bipolar spindle as ...... ty of the mitotic kinesin Eg5.
@nl
type
label
The rate of bipolar spindle as ...... ty of the mitotic kinesin Eg5.
@ast
The rate of bipolar spindle as ...... ty of the mitotic kinesin Eg5.
@en
The rate of bipolar spindle as ...... ty of the mitotic kinesin Eg5.
@nl
prefLabel
The rate of bipolar spindle as ...... ty of the mitotic kinesin Eg5.
@ast
The rate of bipolar spindle as ...... ty of the mitotic kinesin Eg5.
@en
The rate of bipolar spindle as ...... ty of the mitotic kinesin Eg5.
@nl
P2093
P1433
P1476
The rate of bipolar spindle as ...... ty of the mitotic kinesin Eg5.
@en
P2093
Benjamin H Kwok
Janet G Yang
Tarun M Kapoor
P304
P356
10.1016/J.CUB.2004.09.052
P407
P577
2004-10-01T00:00:00Z