Escape in one of two cytotoxic T-lymphocyte epitopes bound by a high-frequency major histocompatibility complex class I molecule, Mamu-A*02: a paradigm for virus evolution and persistence?
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Immunogenicity of seven new recombinant yellow fever viruses 17D expressing fragments of SIVmac239 Gag, Nef, and Vif in Indian rhesus macaquesTCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeysCD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation.Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1Vaccine-elicited memory cytotoxic T lymphocytes contribute to Mamu-A*01-associated control of simian/human immunodeficiency virus 89.6P replication in rhesus monkeys.Unparalleled complexity of the MHC class I region in rhesus macaques.High viremia is associated with high levels of in vivo major histocompatibility complex class I Downregulation in rhesus macaques infected with simian immunodeficiency virus SIVmac239.The role of MHC class I allele Mamu-A*07 during SIV(mac)239 infectionMacaques vaccinated with simian immunodeficiency virus SIVmac239Delta nef delay acquisition and control replication after repeated low-dose heterologous SIV challenge.Tat(28-35)SL8-specific CD8+ T lymphocytes are more effective than Gag(181-189)CM9-specific CD8+ T lymphocytes at suppressing simian immunodeficiency virus replication in a functional in vitro assay.Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239.Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaquesVaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239Transcriptionally abundant major histocompatibility complex class I alleles are fundamental to nonhuman primate simian immunodeficiency virus-specific CD8+ T cell responses.Epitope-specific CD8+ T lymphocytes cross-recognize mutant simian immunodeficiency virus (SIV) sequences but fail to contain very early evolution and eventual fixation of epitope escape mutations during SIV infection.Diverse peptide presentation of rhesus macaque major histocompatibility complex class I Mamu-A 02 revealed by two peptide complex structures and insights into immune escape of simian immunodeficiency virus.A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxviruses.A DNA prime-oral Listeria boost vaccine in rhesus macaques induces a SIV-specific CD8 T cell mucosal response characterized by high levels of alpha4beta7 integrin and an effector memory phenotype.Chinese origin rhesus macaque major histocompatibility complex class I molecules promiscuously present epitopes from SIV associated with molecules of Indian origin; implications for immunodominance and viral escape.Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replicationThe many important facets of T-cell repertoire diversity.In vivo CD8+ T cell control of immunodeficiency virus infection in humans and macaquesThe antiviral efficacy of simian immunodeficiency virus-specific CD8+ T cells is unrelated to epitope specificity and is abrogated by viral escape.Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replication.Selective depletion of high-avidity human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells after early HIV-1 infectionSkewed association of polyfunctional antigen-specific CD8 T cell populations with HLA-B genotypeNef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+ T Cell Killing.Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes.Recognition of escape variants in ELISPOT does not always predict CD8+ T-cell recognition of simian immunodeficiency virus-infected cells expressing the same variant sequences.Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication.The TB-specific CD4(+) T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans.Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu-B*17-positive simian immunodeficiency virus-infected rhesus macaques.CD4+ T cell responses in hepatitis C virus infection.Macaques vaccinated with live-attenuated SIV control replication of heterologous virus.Mauritian cynomolgus macaques share two exceptionally common major histocompatibility complex class I alleles that restrict simian immunodeficiency virus-specific CD8+ T cells.Initiation of antiretroviral therapy 48 hours after infection with simian immunodeficiency virus potently suppresses acute-phase viremia and blocks the massive loss of memory CD4+ T cells but fails to prevent diseaseIs HIV becoming more virulent? Initial CD4 cell counts among HIV seroconverters during the course of the HIV epidemic: 1985-2007.Efficacy of DNA and fowlpox virus priming/boosting vaccines for simian/human immunodeficiency virusA dominant role for CD8+-T-lymphocyte selection in simian immunodeficiency virus sequence variation.Mutations in a dominant Nef epitope of simian immunodeficiency virus diminish TCR:epitope peptide affinity but not epitope peptide:MHC class I binding.
P2860
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P2860
Escape in one of two cytotoxic T-lymphocyte epitopes bound by a high-frequency major histocompatibility complex class I molecule, Mamu-A*02: a paradigm for virus evolution and persistence?
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Escape in one of two cytotoxic ...... rus evolution and persistence?
@ast
Escape in one of two cytotoxic ...... rus evolution and persistence?
@en
Escape in one of two cytotoxic ...... rus evolution and persistence?
@nl
type
label
Escape in one of two cytotoxic ...... rus evolution and persistence?
@ast
Escape in one of two cytotoxic ...... rus evolution and persistence?
@en
Escape in one of two cytotoxic ...... rus evolution and persistence?
@nl
prefLabel
Escape in one of two cytotoxic ...... rus evolution and persistence?
@ast
Escape in one of two cytotoxic ...... rus evolution and persistence?
@en
Escape in one of two cytotoxic ...... rus evolution and persistence?
@nl
P2093
P2860
P50
P1433
P1476
Escape in one of two cytotoxic ...... rus evolution and persistence?
@en
P2093
Austin Hughes
Elizabeth J Dodds
Heather Hickman
Helen Horton
Ivna P De Souza
John Sidney
Kathy Vielhuber
Matthew R Reynolds
Nancy Wilson
Richard Rudersdorf
P2860
P304
11623-11636
P356
10.1128/JVI.76.22.11623-11636.2002
P407
P577
2002-11-01T00:00:00Z