RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos.
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Cortical dynein is critical for proper spindle positioning in human cellsThe RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction faceThe G protein α chaperone Ric-8 as a potential therapeutic targetActivators of G protein signaling exhibit broad functionality and define a distinct core signaling triadB Lymphocyte-Specific Loss of Ric-8A Results in a Gα Protein Deficit and Severe Humoral Immunodeficiency.Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal deathResistance to inhibitors of cholinesterase (Ric)-8A and Gαi contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activityStructural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein Subunit MutantsA P-loop Mutation in Gα Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal PathogenesisCoactivation of G protein signaling by cell-surface receptors and an intracellular exchange factorRic-8: different cellular roles for a heterotrimeric G-protein GEF.A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamicsPAR-3 and PAR-1 inhibit LET-99 localization to generate a cortical band important for spindle positioning in Caenorhabditis elegans embryosHeterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans.Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans.Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos.Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle.F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryoStructure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchangeE2F8 is a nonreceptor activator of heterotrimeric G proteins.A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction.Differential roles of Arabidopsis heterotrimeric G-protein subunits in modulating cell division in roots.Data integration from two microarray platforms identifies bi-allelic genetic inactivation of RIC8A in a breast cancer cell line.Two Galpha(i1) rate-modifying mutations act in concert to allow receptor-independent, steady-state measurements of RGS protein activityA structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration.Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions.Implications of non-canonical G-protein signaling for the immune systemThe nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1.Resistance to inhibitors of cholinesterase 8A catalyzes release of Galphai-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Galphai-GDP complexes.Characterization of the G alpha(s) regulator cysteine string protein.Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells.RETRACTED: Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity.NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha.Increased ubiquitination and the crosstalk of G protein signaling in cardiac myocytes: involvement of Ric-8B in Gs suppression by Gq signal.The guanine nucleotide exchange factor Ric-8A induces domain separation and Ras domain plasticity in Gαi1.Visualization of dynein-dependent microtubule gliding at the cell cortex: implications for spindle positioning.Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization.RIC8 is a guanine-nucleotide exchange factor for Galpha subunits that regulates growth and development in Neurospora crassaPolarity-dependent asymmetric distribution and MEX-5/6-mediated translational activation of the Era-1 mRNA in C. elegans embryosPolarity mediates asymmetric trafficking of the Gbeta heterotrimeric G-protein subunit GPB-1 in C. elegans embryos
P2860
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P2860
RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos.
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
RIC-8 is required for GPR-1/2- ...... ivision of C. elegans embryos.
@ast
RIC-8 is required for GPR-1/2- ...... ivision of C. elegans embryos.
@en
RIC-8 is required for GPR-1/2- ...... ivision of C. elegans embryos.
@nl
type
label
RIC-8 is required for GPR-1/2- ...... ivision of C. elegans embryos.
@ast
RIC-8 is required for GPR-1/2- ...... ivision of C. elegans embryos.
@en
RIC-8 is required for GPR-1/2- ...... ivision of C. elegans embryos.
@nl
prefLabel
RIC-8 is required for GPR-1/2- ...... ivision of C. elegans embryos.
@ast
RIC-8 is required for GPR-1/2- ...... ivision of C. elegans embryos.
@en
RIC-8 is required for GPR-1/2- ...... ivision of C. elegans embryos.
@nl
P2093
P1433
P1476
RIC-8 is required for GPR-1/2- ...... ivision of C. elegans embryos.
@en
P2093
Christopher A Johnston
Christopher R McCudden
Francis S Willard
Katayoun Afshar
Kelly Colombo
P304
P356
10.1016/J.CELL.2004.09.026
P407
P577
2004-10-01T00:00:00Z